가토 동맥경화에서의 matrix metalloproteinase-3 = Matrix Metalloproteinase-3 in Atherogenesis in Rabbits

다국어 초록 (Multilingual Abstract)

A relation between atherogenesis and expression of a type of gelatinase, matrix metalloproteinase3 (MMP-3) was investigated in male New Zealand White Rabbits. Lesion development and immunohistochemical reaction for anti-MMP-3 were measured in the aorta. After 4 months of provocation of atherosclerosis with a hyperlipidemic diet, the rabbits were divided into a hyperlipidemic diet group, a normal diet group, and a hyperlipidemic plus phytoestrogen diet group. Normal feeding continued for an additional 4 months. Atherosclerotic lesions developed mildly during the provocation period (0.269mm^(2)). Lesion development progressed due to continuous hyperlipidemic diet (10.06mm^(2)) but was partly inhibited by phytoestrogen (0.997mm^(2)). A normal diet resulted in slight decrease in the lesion size (0.228mm^(2)). The immunohistochemistry for anti-MMP-3 showed a diffuse reaction along the endothelium and foamy cells within the lesion. The normal diet group revealed slight decrease the intensity compared to the other groups. Atherosclerosis induced by a hyperlipidemic diet can be inhibited by phytoestrogen in rabbits. A hyperlipidemic diet may stimulate MMP-3 in the aorta of rabbits.