<P>Beta-cell loss is a major cause of the pathogenesis of diabetes. Elevated levels of free fatty acids may contribute to the loss of <I>β</I>-cells. Using a transgenic zebrafish, we screened ~50 seaweed crude extracts to identi...
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https://www.riss.kr/link?id=A107463140
2018
-
SCOPUS
학술저널
4973851
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P>Beta-cell loss is a major cause of the pathogenesis of diabetes. Elevated levels of free fatty acids may contribute to the loss of <I>β</I>-cells. Using a transgenic zebrafish, we screened ~50 seaweed crude extracts to identi...
<P>Beta-cell loss is a major cause of the pathogenesis of diabetes. Elevated levels of free fatty acids may contribute to the loss of <I>β</I>-cells. Using a transgenic zebrafish, we screened ~50 seaweed crude extracts to identify materials that protect <I>β</I>-cells from free fatty acid damage. We found that an extract of the red seaweed <I>Polysiphonia japonica</I> (PJE) had a <I>β</I>-cell protective effect. We examined the protective effect of PJE on palmitate-induced damage in <I>β</I>-cells. PJE was found to preserve cell viability and glucose-induced insulin secretion in a pancreatic <I>β</I>-cell line, Ins-1, treated with palmitate. Additionally, PJE prevented palmitate-induced insulin secretion dysfunction in zebrafish embryos and mouse primary islets and improved insulin secretion in <I>β</I>-cells against palmitate treatment. These findings suggest that PJE protects pancreatic <I>β</I>-cells from palmitate-induced damage. PJE may be a potential therapeutic functional food for diabetes.</P>
Antioxidant and Cell-Signaling Functions of Hydrogen Sulfide in the Central Nervous System