Endorphin의 心脈關系 調節에 關한 硏究 = Modulatory Effect of Endorphin on Cardiovascular System

다국어 초록 (Multilingual Abstract)

Experiments were designed to evaluate the role of β-endorphin in the central cardiovascular control of the two-kidney on clipped hypertensive rats.
1. In the two-kidney one-clipped rat, blood pressure was significantly increased after 7 days of operation, whereas heart rate did not change.
2. In these preparations, β-endorphin contents in brain were significantly increased es-pecially in hypothalamus, medulla and pons, while decreases of maximum specific(^3H)-mor-phino binding were observed in thalamus, hypothalamus, medulla and pone.
3. Decreasing effects of intraventricular morphine on blood pressre and heart rate was potentiated in the two-kidney one-clipped hypertensive rats. These effects of intraventricular morphine were not blocked by intraventricular phenotolamine, phenoxybenzamine, yohimbine, piperoxan or prazosin, but by intraventricular naloxone.
4. In the two-kidney one-clipped hypertensive rats, decreasing effects of intraventricular clonidine on blood pressure and heart rate were potentiate. These effects of clonidine were inhibited by intraventricular naloxone.
From the above results, it is suggested that changes of β-endorphin contents and opiate receptors in brain will take a role of centrol cardiovascular control of two-kidney one-clipped hypertensive rats by modulating the central cardiovascular control of two-kidney one-clipped hypertensive rats by modulating the central stmpathetic activity through a_2-adrenergic receptors.
(Key words: endorphin, cardiovascular system)