Overview for Various Aspects of the Health Benefits of Piper Longum Linn. Fruit

다국어 초록 (Multilingual Abstract)

Herbal remedies have become popular, due in part to the lower risk of adverse reactions. Thousands of plants have been used traditionally to treat various diseases.
Among them, species of the genus Piper are important medicinal plants used in various systems of medicine. The Piper longum fruit has been used in traditional medicine, including the Ayurvedic system of medicine. Although there are numerous indications for its use, controlled trials are needed to determine its efficacy. The primary constituents isolated from various parts of P. longum are piperine, piperlongumine,sylvatin, sesamin, diaeudesmin piperlonguminine, pipermonaline, and piperundecalidine. It is most commonly used to treat chronic bronchitis, asthma,constipation, gonorrhea, paralysis of the tongue, diarrhea, cholera, chronic malaria,viral hepatitis, respiratory infections, stomachache, bronchitis, diseases of the spleen, cough, and tumors. This study provides detailed information about the P. longum fruit, including phytochemistry, pharmacological profile and safety profile.
In view of the commercial, economic, and medicinal importance of the P. longum plant, it is useful for researchers to study the plant in detail.

참고문헌 (Reference)

1 Sun XX, "Theeag potassium channel binds and locally activates calcium/calmodulin-dependent protein kinase II" 279 : 10206-10214, 2004

2 "Scirus search engine"

3 "ScienceDirect"

4 Chanda D, "Safety evaluation of Trikatu, a generic Ayurvedic medicinein Charles foster rats" 34 : 99-108, 2009

5 Wakade AS, "Protectiveeffect of Piper longum L. on oxidative stress induced injuryand cellular abnormality in adriamycin induced cardiotoxicityin rats" 46 : 528-533, 2008

6 Sunila ES, "Protective effect of Piper longum fruitethanolic extract on radiation induced damages in mice: apreliminary study" 76 : 649-655, 2005

7 Ghoshal S, "Potential antiamoebic property of theroots of Piper longum Linn" 16 : 689-691, 2002

8 Khajuria A, "Piperine modulates permeabilitycharacteristics of intestine by inducing alterations inmembrane dynamics: influence on brush border membranefluidity, ultrastructure and enzyme kinetics" 9 : 224-231, 2002

9 Lee SA, "Piperine from the fruits of Piper longum with inhibitoryeffect on monoamine oxidase and antidepressant/like activity" 53 : 832-835, 2005

10 Hong SS, "Piperine from the fruits of Piper longum with inhibitoryeffect on monoamine oxidase and antidepressant-like activity" 53 : 832-835, 2005

11 Shoji N, "Ohizumi Dehydropipernonaline, an amide possessing coronaryvasodilating activity, isolated from Piper longum L" 75 : 1188-1189, 1986

12 Kumar S, "Novel aromatic ester from Piper longum and its analoguesinhibit expression of cell adhesion molecules onendothelial cells" 44 : 15944-15952, 2005

13 National Institutes of Health, "National Center forBiotechnology Information. PubMed"

14 "Multilingual multiscript plant name database"

15 Seon A Lee, "Methylpiperate Derivatives from Piper longum and Their Inhibition of Monoamine Oxidase" 대한약학회 31 (31): 679-683, 2008

16 Seon A Lee, "Methylpiperate Derivatives from Piper longum and Their Inhibition of Monoamine Oxidase" 대한약학회 31 (31): 679-683, 2008

17 Choudhary GP, "Mast cell stabilizing activity of piper longumLinn" 20 : 112-116, 2006

18 Dutt CP, "Lignans in the seeds of Piperlongum" 14 : 2090-2091, 1975

19 Chaithong U, "Larvicidal effect ofpepper plants on Aedes aegypti (L.) (Diptera: Culicidae)" 31 : 138-144, 2006

20 Anuradha V, "Isolation and synthesis ofisodihydropiperlonguminine" 18 : 247-251, 2004

21 Kim KS, "Inhibitoryeffect of piperlonguminine on melanin production inmelanoma B16 cell line by downregulation of tyrosinaseexpression" 19 : 90-98, 2006

22 Iwashita M, "Inhibitory effect of ethanol extract of Piper longum L. onrabbit platelet aggregation through antagonizing thromboxaneA2 receptor" 14 : 853-855, 2007

23 이승웅, "Inhibition of diacylglycerol acyltransferase by alkamides isolated from the fruits of Piper longum and Piper nigrum" American Chemical Society 54 (54): 9759-9763, 200612

24 Christina AJ, "Inhibition of CCl4induced liver fibrosis by Piper longum Linn" 13 : 196-218, 2006

25 Kirtikar KR, "Indian Medicinal Plants" Orients Longman 21-28, 1980

26 Sunila ES, "Immunomodulatory and antitumor activityof Piper longum Linn. and piperine" 90 : 339-346, 2004

27 "Google India"

28 Lee SE, "Fungicidal activity of pipernonaline, a piperidine alkaloidderived from long pepper, Piper longum L., against phytopathogenicfungi" 20 : 523-528, 2001

29 Koul IB, "Evaluation of the liver protective potentialof piperine, an active principle of black and long peppers" 59 : 413-417, 1993

30 Tiwari RC, "Efficient interval estimation forage-adjusted cancer rates" 15 : 547-569, 2006

31 Pattanaik S, "Effect of piperine on the steady-state pharmacokinetics ofphenytoin in patients with epilepsy" 20 : 683-686, 2006

32 Pradeep CR, "Effect of piperine on the inhibitionof lung metastasis induced B16F/10 melanoma cells inmice" 19 : 703-708, 2002

33 Rastogi RP, "Compendium of Indian MedicinalPlants" CDRI, Luckhnow and New Delhi, India: Nisc 504-857, 1993

34 "Ayushveda health and lifestyle portal"

35 Desai SJ, "Aristolactams and4,5-dioxoaporphines from Piper longum" 27 : 1511-1515, 1988

36 Park BS, "Antiplateleteffects of acidamides isolated from the fruits of Piperlongum L" 14 : 853-855, 2007

37 Natarajan KS, "Antioxidant activity of a salt/spice/herbal mixture against free radical induction" 105 : 76-83, 2006

38 Ali AM, "Antimicrobial screening of different extracts of Piper longumLinn" 3 : 852-857, 2007

39 Jin Z, "Antihyperlipidemic compounds from the fruit of Piperlongum L" 23 : 1194-1196, 2009

40 Tripathi DM, "Antigiardial and immunostimulatory effect of Piper longumon giardiasis due to Giardia lamblia" 13 : 561-565, 1999

41 Lakshmi V, "Antifertilityactivity of Piper longum Linn. in female rats" 20 : 235-239, 2006

42 Vedhanayaki G, "Analgesic activity ofPiper longum Linn. root" 41 : 649-651, 2003

43 C.Varshneya, "Alteration of pharmacokinetics of oxytetracycline following oral administration of Piper longum in hens" 대한수의학회 6 (6): 197-200, 2005

44 Chatterjee A, "Alkaloids of Piper longum Linn. I.Structure and synthesis of piperlongumine and piperlonguminine" 23 : 1769-1781, 1967

45 Choochote W, "Adulticidal activityagainst Stegomyia aegypti (Diptera: Culicidae) of three Piperspp" 48 : 33-37, 2006

46 Yang YC, "A piperidineamide extracted from Piper longum L. fruit showsactivity against Aedes aegypti mosquito larva" 19 : 3765-3767, 2002