위장관 암종에서의 Class Ⅰ 조직적합항원의 발현에 대한 면역조직화학적 연구 = An Immunohistochemical Study of HLA Class I Antigens in Gastrointestinal Cancer

다국어 초록 (Multilingual Abstract)

Expression of HLA class I antigens was studied by immunohistochemical staining of acetone-fixed cryostat sections of 6 gastric and 10 colorectal adenocarcinomas using monoclonal antibodies. Immunohistochemical staining for MB-2(pan-B cell marker) and UCHL-1(pan-T cell marker) was also performed on formalin-fixed, paraffin embedded tissues in order to analyse tumor-infiltrating lymphocytes. HLA class I antigens were strongly expressed in normal gastric and colorectal epithelium. In 6 gastric adenocarinomas, which were all poorly differentiated, the expression intensity of HLA class I antigens was mildly decreased, compared to normal epithelium. Among 10 colorectal adenocarcinomas, one mucinous carcinoma was completely negative. The remaining were positive, although the expression intensity was somewhat decreased in moderately differentiated adenocarcinomas. The mononuclear infiltrate in the gastric and colorectal carcinomas consisted mainly of T-cells, although the infiltrate was relatively sparse and sometimes absent.
There was no apparent correlation between the degree of differentiation, the intensity of T-cell infiltrates, and HLA class I antigen expression. However, a relatively poor expression of HLA class I antigens was found in association with a decrease in the degree of histologic differentiation.