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      환경 독성 억제효과를 가진 커큐민 나노스피어가 마우스의 사료 효율 및 악취저감에 미치는 영향 = Effects of Anti-ecotoxicological Curcumin Nanospheres on Feed Efficiency and Fecal Odor in Mice

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      https://www.riss.kr/link?id=A106089968

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      다국어 초록 (Multilingual Abstract)

      Curcumin (C<sub>21</sub>H<sub>20</sub>O<sub>6</sub>) is a hydrophobic polyphenol found in turmeric. Although curcumin has been used as a natural medicine, its major limitation is related to poor absorption from the gut. Therefore, we developed a method for preparation of Curcumin Nanospheres (CN) to improve the aqueous-phase solubility of curcumin and investigate the functional role of CN in promoting feed efficiency and odor reduction in mice. CN showed inhibitory effects on actate dehydrogenase (LDH) cytotoxicity induced by ecotoxic substance toluene in gut epithelial HCT116 cells. In addition, the weights of internal organs (liver, heart, kidneys, and spleen) and the levels of serum Glutamate Oxaloacetate Transaminase (GOT), Glutamate Pyruvate Transaminase (GPT), and LDH did not show significant differences between mice administered oral CN for two weeks and compared to the control group. Interestingly, CN not only reduced hydrogen sulfide (H<sub>2</sub>S) and ammonia (NH<sub>3</sub>) levels and fecal odor, but also improved feed efficiency in mice. These results demonstrate that oral nano-delivery of anti-ecotoxicological CN is a functional system to deliver curcumin to the gut to improve feed efficiency and reduce fecal odor in mice.
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      Curcumin (C<sub>21</sub>H<sub>20</sub>O<sub>6</sub>) is a hydrophobic polyphenol found in turmeric. Although curcumin has been used as a natural medicine, its major limitation is related to poor absorption from the ...

      Curcumin (C<sub>21</sub>H<sub>20</sub>O<sub>6</sub>) is a hydrophobic polyphenol found in turmeric. Although curcumin has been used as a natural medicine, its major limitation is related to poor absorption from the gut. Therefore, we developed a method for preparation of Curcumin Nanospheres (CN) to improve the aqueous-phase solubility of curcumin and investigate the functional role of CN in promoting feed efficiency and odor reduction in mice. CN showed inhibitory effects on actate dehydrogenase (LDH) cytotoxicity induced by ecotoxic substance toluene in gut epithelial HCT116 cells. In addition, the weights of internal organs (liver, heart, kidneys, and spleen) and the levels of serum Glutamate Oxaloacetate Transaminase (GOT), Glutamate Pyruvate Transaminase (GPT), and LDH did not show significant differences between mice administered oral CN for two weeks and compared to the control group. Interestingly, CN not only reduced hydrogen sulfide (H<sub>2</sub>S) and ammonia (NH<sub>3</sub>) levels and fecal odor, but also improved feed efficiency in mice. These results demonstrate that oral nano-delivery of anti-ecotoxicological CN is a functional system to deliver curcumin to the gut to improve feed efficiency and reduce fecal odor in mice.

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      참고문헌 (Reference)

      1 이병관, "환경기초시설에서 발생하는 악취가스 제거에 관한 연구" 한국기후변화학회 8 (8): 51-56, 2017

      2 박순자, "강황, 커피염색 면직물의 위생학적 성능과 Printing의 영향 평가" 한국지역사회생활과학회 28 (28): 143-154, 2017

      3 Lee, K. H., "The effect of horseradish powder level in fattening pig diet on odorous compound concentration from manure" 18 : 41-46, 2012

      4 Williams, A. G., "Storage of piggery slurry" 3 : 311-321, 1981

      5 Spoelstra, S. F., "Simple phenols and indoles in anaerobically stored piggery wastes" 28 : 415-423, 1977

      6 Sharma, R. A., "Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer" 7 : 1894-1900, 2001

      7 Gera, M., "Nanoformulations of curcumin : an emerging paradigm for improved remedial application" 8 : 66680-66698, 2017

      8 Ozaki, M., "Ebselen, a novel anti-oxidant compound, protects the rat liver from ischemia-reperfusion injury" 10 : 96-102, 1997

      9 Morvai, V., "ECG changes in benzene, toluene and xylene poisoned rats" 33 : 275-286, 1976

      10 Liu, C. H., "Development and characterization of eucalyptol microemulsions for topic delivery of curcumin" 59 : 172-178, 2011

      1 이병관, "환경기초시설에서 발생하는 악취가스 제거에 관한 연구" 한국기후변화학회 8 (8): 51-56, 2017

      2 박순자, "강황, 커피염색 면직물의 위생학적 성능과 Printing의 영향 평가" 한국지역사회생활과학회 28 (28): 143-154, 2017

      3 Lee, K. H., "The effect of horseradish powder level in fattening pig diet on odorous compound concentration from manure" 18 : 41-46, 2012

      4 Williams, A. G., "Storage of piggery slurry" 3 : 311-321, 1981

      5 Spoelstra, S. F., "Simple phenols and indoles in anaerobically stored piggery wastes" 28 : 415-423, 1977

      6 Sharma, R. A., "Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer" 7 : 1894-1900, 2001

      7 Gera, M., "Nanoformulations of curcumin : an emerging paradigm for improved remedial application" 8 : 66680-66698, 2017

      8 Ozaki, M., "Ebselen, a novel anti-oxidant compound, protects the rat liver from ischemia-reperfusion injury" 10 : 96-102, 1997

      9 Morvai, V., "ECG changes in benzene, toluene and xylene poisoned rats" 33 : 275-286, 1976

      10 Liu, C. H., "Development and characterization of eucalyptol microemulsions for topic delivery of curcumin" 59 : 172-178, 2011

      11 Jemal, A., "Cancer statistics, 2005" 55 : 10-30, 2005

      12 Ravindranath, V., "Absorption and tissue distribution of curcumin in rats" 16 : 259-265, 1980

      13 Wahlstrom, B., "A Study on the fate of curcumin in the rat" 43 : 86-92, 1978

      14 Reitman, S., "A Colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases" 28 : 56-63, 1957

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      공동연구자 (7)

      유사연구자 (20) 활용도상위20명

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2027 평가예정 재인증평가 신청대상 (재인증)
      2021-01-01 평가 등재학술지 유지 (재인증) KCI등재
      2018-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2015-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2013-02-19 학술지명변경 외국어명 : JOURNAL OF THE ENVIRONMENTAL SCIENCES -> JOURNAL OF ENVIRONMENTAL SCIENCE INTERNATIONAL KCI등재
      2011-05-16 학술지명변경 외국어명 : 미등록 -> JOURNAL OF THE ENVIRONMENTAL SCIENCES KCI등재
      2011-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2009-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2007-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2005-03-22 학술지명변경 외국어명 : 미등록 -> journal of the environmental sciences KCI등재
      2004-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      2003-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      2002-01-01 평가 등재후보학술지 유지 (등재후보1차) KCI등재후보
      2001-01-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.37 0.37 0.38
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.36 0.35 0.525 0.1
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