Evaluation of the Anti-osteoporosis and Antioxidant Activities of Phenolic Compounds from Euphorbia maculata

다국어 초록 (Multilingual Abstract)

Antioxidant and anti-osteoporosis activities of extractsand chemical constituents from the whole plant of Euphorbiamaculata were investigated. The MeOH extract, as well as EtOAcand H2O fractions (10.0 μg/mL), exhibited potent antioxidantactivities. Their oxygen radical absorbance capacity and cupricion reducing antioxidant capacity values were 27.07±0.31 to28.47±0.36 and 43.86±0.26 to 46.67±0.34 fold higher than thoseof 1.0 μM Trolox, respectively. The MeOH extract and EtOAcfraction (at 10.0 μg/mL) also significantly suppressed excessivebone resorption by osteoclasts with tartrate-resistant acid phosphatase(TRAP) activity values of 154.90±4.25 and 163.95±9.77%,respectively. Bioassay guided isolation of the EtOAc and H2Ofractions afforded 19 known compounds (1−19). Of these,compounds 18, and 13−15 showed good antioxidant activitybased on peroxyl radical-scavenging and reducing capacity assays,whereas compounds 1, 4, 7, and 14 showed the most significantinhibitory effect with TRAP activity values ranging from 121.31±1.41 to 110.00±3.74% relative to the control.

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