Protein Adsorption and Bacterial Adhesion Resistance of Cross-linked Copolymer Hydrogels Based on Poly(2-methacryloyloxyethyl phosphorylcholine) and Poly(2-hydroxyethyl methacrylate)

다국어 초록 (Multilingual Abstract)

Herein, the preparation of the cross-linked copolymer hydrogels composed of various weight ratios of 2-methacryloyloxyethyl phosphorylcholine (MPC) and 2-hydroxyethyl methacrylate (HEMA) monomers employing free-radical polymerization was reported. The integration of the MPC monomer into HEMA-based hydrogels showed good transmittance (>90%) and enhanced the water content retention (79?202%) relative to those of pure HEMA-based hydrogel. Notably, the MPC-containing hydrogels (MPC-H) exhibited the improved anti-biofouling properties due to the formation of a compact hydration layer produced by the biomimetic MPC units at the hydrogel surface. MPC-H exhibited a decrease in the bovine serum albumin (BSA) and lysozyme adsorption of approximately 40?70% and 44?65%, respectively, relative to those of control hydrogel without MPC monomer. The results presented herein demonstrate the potential of expending biocompatible monomers such as HEMA and MPC to efficiently generate a biomaterial that possesses both bio-membrane mimicking character and protein and bacterial resistant properties for various industrial and biomedical applications.

참고문헌 (Reference)

1 S. Jiang, 100 : 4-, 2016

2 Q. Sheng, 99 : 11018-, 1995

3 J. A. Callow, 2 : 244-, 2011

4 P. B. Messersmith, 2 : 138-, 2007

5 M. He, 40 : 142-, 2016

6 K. B. Green-Church, 14 : 456-, 2008

7 T. Goda, 132 : 1-, 2015

8 R. J. Fullard, 32 : 2290-, 1991

9 W. Norde, 13 : 363-, 1992

10 B. D. Ratner, 6 : 41-, 2004

11 T. Goda, 89 : 184-, 2009

12 K. Ishihara, 39 : 323-, 1998

13 Z. Zhang, 110 : 10799-, 2006

14 W. Zhang, 28 : 1935-, 2017

15 H. Ma, 16 : 338-, 2004

16 Y. -L. Su, 329 : 246-, 2009

17 W. R. Gombotz, 25 : 1547-, 1991

18 C. Perrino, 24 : 8850-, 2008

19 K. Ishihara, 22 : 55-, 1990

20 V. W. L. Ng, 78 : 46-, 2014

21 L. Zhang, 31 : 553-, 2013

22 S. Jiang, 22 : 920-, 2010

23 F. Xuan, 58 : 1350-, 2009

24 S. Chen, 127 : 14473-, 2005

25 L. Li, 47 : 1795-, 2011

26 M. Van Beek, 19 : 1425-, 2008

27 M. Van Beek, 29 : 780-, 2008

28 J. -H. Seo, 29 : 1367-, 2008

29 S. Chen, 51 : 5283-, 2010

30 J. A. K. Noumedem, 2 : 503-, 2013

31 J. J. Rojas, 6 : 2-, 2006

32 황유식, "Microwell-Mediated Cell Spheroid Formation and Its Applications" 한국고분자학회 26 (26): 1-8, 2018

33 김호중, "Hydrogel Lenses Functionalized with Polysaccharide for Reduction of Protein Adsorption" 한국고분자학회 23 (23): 74-78, 2015

34 임화림, "Hyaluronic acid의 첨가방법에 따른 하이드로겔 콘택트렌즈의 물리적 특성과 lysozyme 흡착량 비교" 한국안광학회 20 (20): 285-291, 2015

35 지준필, "Development of Hydrogel Lenses with Surface-immobilized PEG Layers to Reduce Protein Adsorption" 대한화학회 36 (36): 2682-2687, 2015