Poster Session : PS-1575 ; Diagnostic : Association Between Cigarette Smoking and Serum Gamma-Glutamyl Transferase Level = Poster Session : PS-1575 ; Diagnostic : Association Between Cigarette Smoking and Serum Gamma-Glutamyl Transferase Level

다국어 초록 (Multilingual Abstract)

Background: Gamma-glutamyltransferase (GGT) is an enzyme mainly produced from the cells of the hepatobiliary tract. And, It has been introduced as a biomarker for oxidative stress by smoking as well as alcohol consumption. This study was performed to evaluate the association between smoking and serum GGT concentration Methods: The effect of cigarette smoking on serum activities of the enzyme, GGT was investigated using the data of the 5th Korea National Health and Nutrition Examination Survey (5th KNHANES, 2010 to 2012); a cross-sectional survey in the general population of Korea. Results: We analyzed 11,670 subjects (age> 19 years) who had the data about smoking status and serum GGT levels. Subjects comprised 4,597 subjects who are cigarette smokers and 7,073 who do not smoke, which serves as control. The mean ± standard deviation (S.D) of serum GGT levels in cigarette smokers and non-smokers were 48.74± 69.35 U/L and 23.18± 24.03 U/L respectively, showing a significant increase in serum level of GGT (P<0.001) when compared with controls. GGT levels showed a significant positive correlation with amount of smoking (r=0.249, P<0.001). Cigarette smoking produced a significant increase in GGT activity irrespective of low to moderate alcohol consumption Conclusions: The levels of serum GGT was significantly associated with the status and amount of smoking. Smoking should be taken into account when assessing the signifi-cance of GGT activities.