Thiothixene이 가토 혈중 주정농도에 미치는 영향에 관한 실험적 연구 = EFFECTS OF THIOTHIXENE ON BLOOD ALCOHOL LEVEL IN RABBITS

다국어 초록 (Multilingual Abstract)

Thiothixene, which is a thioxanthene derivative, has been used in treatment of schizophrenia. The efficacy of this drug has been frequently compared to other neuroleptics, such as chlorpromazine, thioridazine and trifluoperazine. This drug has been known to cause some extrapyramidal symptoms and hypotensive effects but these side effects have been considered to be less marked than the extrapyramidal and hypotensive effects of most of other neuroleptics.
It has been lately reported that chlorpromazine, lithium ion and several other
psychotropic drugs elevated the blood alcohol level in rabbits.
In view of these findings, the author conducted an animal experiment to investigate the effects of thiothixene on blood alcohol level in rabbits.
Materials and method
1. Experimental work was done with mature rabbits of both sexes, weighing about
2.0kg.
2. The experiment was done in two groups; control and experimental group.
Experimental group was divided into four subgroups; alcohol＋thiothixene (5mg/kg, for 5 days), alcohol＋thiothixene (5mg/kg, for 10 days), alcohol＋thiothixene (10mg/kg, for 5days) and alcohol＋thiothixene (10mg/kg, for 10 days).
3. Control group was given alcohol only, and in the first subgroup thiothixene was given 5mg/kg of body weight, daily for 5 days, in the second subgroup, thiothixene was given 5mg/kg of body weight, daily for 10 days, in the third group, thiothixene was given 10mg/kg of body weight, daily for 5 days, and in the forth group thiothixene was given 10mg/kg of body weight, daily for 10 days.
4. In all groups, 20 vol. % ethanol solution was given, in a dose of 5.0ml/kg of body weight, at a constant rate for 5 minutes, by intravenous route.
5. All of the blood specimens were obtained by cardiac puncture at 15 and 45 minutes respectively after alcohol administration.
6. The blood alcohol level was determined by Cavett's method.
Results
1. Alcohol＋thiothixene (5mg/kg, for 5 days) subgroup. In this group, thiothixene lowered the blood alcohol level significantly at both 15 minutes (P＜0.01) and 45 minutes (P＜0.01) after alcohol administration.
2. Alcohol＋thiothixene (5mg/kg, for 10 days) subgroup. In this group, thiothixene lowered the blood alcohol level significantly at both 15 minutes (P＜0.001) and 45 minutes (P＜0.001) after alcohol administration.
3. Alcohol＋thiothixene (10mg/kg, for 5 days) subgroup. Thiothixene lowered the blood alcohol level significantly at both 15 minutes (P＜0.001) and 45minutes (P＜0.001) after alcohol administration.
4. Alcohol＋thiothixene (10mg/kg, 10 days) subgroup. Thiothixene lowered the blood alcohol level significantly at both 15 minutes (P＜0.001) and 45 minutes (P＜0.001) after alcohol administration.
Conclusion
1. The orally administered thiothixene in a dose of 5mg/kg/day for 5 days lowered significantly the blood alcohol level in rabbits at 15 minutes and at 45 minutes after alcohol administration.
2. The orally administered thiothixene in a dose of 5 mg/kg/day for 10 days lowered significantly the blood alcohol level in rabbits at 15 minutes and 45 minutes after alcohol administration.
3. The orally administered thiothixene in a dose of 10 mg/kg/day for 5 days lowered significantly the blood alcohol level in rabbits at 15 minutes and at 45 minutes after alcohol administration.
4. The orally administered thiothixene in a dose of 10 mg/kg/day for 10 days lowered significantly the blood alcohol level in rabbits at 15 minutes and at 45 minutes after alcohol administration.