두뇌손상과 혈장내 CPK(creatine phosphokinase) 수치와의 관계 = Creatine Phosphokinase in Blood after Acute Brain Injury

다국어 초록 (Multilingual Abstract)

Acute tissue damage usually releases intracellular enzymes into the circulat-ion. The serum level of CPK is a sensitive indicator of muscle cell damage12). Recent publications have shown that its estimation is useful in the diagnosis and prognosis of primary muscle disease and myocardial infarction22)32).
Since brain tissue contains high concentrations of CPK, acute brain damage
is followed by increased CPK activity in the serum2)31)25)37)
We here present some observations on the levels of CPK in the sera of pati-ents with acute brain damage, who were admitted to the department of neuro-surgery in the National Medical Center. Of 36 patients with acute brain damage, 13 had raised serum, CPK value. Especially of 12 patients with cerebral contusion, 7 had raised serum CPK value and 2 patients were expired. Total serum CPK activity was pathological in 3 of 12 patients with cerebral concuss-ion and subarachnoid hemorrhage respectively and these value was lower than that of cerebral contusion.
So that we may consider as there is some correlation’s between the increased serum CPK value and the degree of brain damage. In other neuromuscular disorders, we found increased serum CPK value in one of 4 cerebrovascular occlusive diseases, all of 2 meningitis and one progressive muscular dystrophy. 5 patients of brain tumor had normal serum CPK activity.
We measured the total serum CPK activity by means of Sigma Technic Procedure No. 661 (colorimetric) with a Beckman spectrophotometer (620-700 nm).