상피성 종양에서의 Cyclooxygenase-2 발현에 대한 면역조직화학적 관찰 = Immunohistochemical Studies of Cyclooxygenase-2 Expression in Epithelial Neoplasms

다국어 초록 (Multilingual Abstract)

To evaluate cyclooxygenase-2 (COX-2) expression in various epithelial neoplasms, immunohistochemical study was done to 65 cases of various carcinomas and tubular adenomas. This study included 10 cases of colonic adenocarcinom, 10 cases of gastric adenocarcinoma, 10 cases of pulmonary carcinoma, 10 cases of mammary carcinoma, 5 cases of hepatic adenocarcinoma, 5 cases of urinary bladder carcinoma and 5 cases of prostatic carcinoma. 10 cases of tubular adenoma in colon and stomach. The frequency of immunohistochemical COX-2 expression of varying degree in various carcinomas was observed, and the immuno-histochemical intensity showed increasing tendency by degree of differentiation. The immunohistochemical expression of COX-2 was observed in tubular adenoma of stomach and colon, and strongly expressed in metastatic colonic adenocarcinoma than primary carcinomas of various sites. Therefore, the above results suggest that COX-2 expression in various carcinomas may be related to the early and late stage of tumor progression.

목차 (Table of Contents)

• 서론
• 재료 및 방법
• 1. 연구재료
• 2. 연구방법
• 3. 염색결과의 판정
• 연구결과
• 1. 상피성 종양의 부위에 따른 COX-2 과발현의 빈도
• 2. 상피성 종양에서 분화도에 따른 COX-2 발현의 양상
• 고찰
• 결론