Lactic Acid의 심근 수축성에 미치는 영향 = The Effects of Lactic Acid on the Contractility of the Isolated Perfused Heart

다국어 초록 (Multilingual Abstract)

In order to evaluate the effects of lactice acid on the cardiac muscle contractility, turtle Ringer solution contained various concentration of lactic acid or HCl were perfused into isolated turtle ventricle by Langendrof preparation and contractility parameters, such as tension, maximal contraction dT/dt, and maximal relaxation dT/dt were measured by Physiograph. Lactic acid depressed remarkably the contractility parameters of the heart and the magnitude of depression was about 23-28 percent with decrease in one unit of pH at the pH range between 6.80 and 8.20. Furthermore the degree of inhibition of contractility parameters between lactic acid and HCl were not significant differance statistically. Therefore it was suggested that inhibitory effect of cardiac muscle contractility by lactic acid may depend on hydrogen ion concentration, ie. pH.