Manganese single-atom nanostructures for highly efficient tumor therapy

다국어 초록 (Multilingual Abstract)

The single-atom attracts growing interests in various fields and provides a new strategy for tumor therapyby inspiring chemodynamic-photothermal therapy (CPT) effects owing to its excellent catalytic properties.
We synthesize the Folic acid@single atomic manganese (Mn) nanoparticles (FA@SAMn NPs) withmesoporous carbon sphere structure by the coordination aided polymerization assembly method.
Antitumor therapeutic effect studies were carried out in vitro and in vivo. This hierarchical nanostructurepossesses a high surface area, large pore, and rich N that provide higher catalytic activity, and it also exhibitsexcellent activity and stability in the oxygen reduction reaction. With its accumulation in the specifictumor microenvironment, the FA@SAMn NPs could generate reactive oxygen species (ROS), which wouldmediate a series of 4 T1 cell damage and inhibit tumor propagation (56% mortality rate). Moreover, theFA@SAMn NPs possess an excellent photothermal effect under near infrared-II (NIR-II) laser irradiation.
This leads to a local hyperthermia situation in the tumor area and contributes to tumor inhibition (91%mortality rate). In sum, FA@SAMn catalysts effectively suppressed tumor growth and significantlyincreased the survival time. This work aims to provide new potential single-atom-coordinated carbonnetworks that possess efficient biocatalytic sites and photothermal effects, inspiring a series of advancesin ROS and photothermal-related biological applications across broad biomedical fields.

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