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      KCI등재 SCIE SCOPUS

      Efficacy of Salvage Interferential Electrical Stimulation Therapy in Patients With Medication-Refractory Enuresis: A Pilot Study

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      https://www.riss.kr/link?id=A101597381

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      다국어 초록 (Multilingual Abstract)

      Purpose: In pediatric patients with enuresis, the protocol for salvage therapy in patients in whom first-line therapy was not successful has not yet been established. Interferential electrical stimulation (IF-ES) therapy is advantageous because it is ...

      Purpose: In pediatric patients with enuresis, the protocol for salvage therapy in patients in whom first-line therapy was not successful has not yet been established. Interferential electrical stimulation (IF-ES) therapy is advantageous because it is noninvasive and shows high compliance. We aimed to investigate the efficacy and safety of IF-ES therapy on pediatric enuresis in a pilot study.
      Methods: We investigated 10 patients who underwent IF-ES therapy between August 2012 and March 2013 at our clinic. Patients with a history of previous treatment with desmopressin and anticholinergic agents for at least 3 months and those in whom alarm treatment previously failed or was refused by parents were eligible. Electrical current was given starting at approximately 20 mA and was increased until the patient complained of discomfort. Treatment was performed once a week, 20 minutes per treatment, 6 times per cycle. After each cycle, an interview was performed and voiding diaries were filled. The physician in charge evaluated improvement according to the International Children’s Continence Society criteria.
      Results: A final analysis was performed in 10 patients (5 male and 5 female patients) in whom therapy for nocturnal enuresis had failed. Eight patients had nonmonosymptomatic enuresis and 2 had monosymptomatic enuresis. The mean age of the patients was 8.5±2.4 years, and the mean number of treatments was 10.6±3.6 times. A full response was observed in 1 patient (10%); a good response, in 1 patient (10%); a partial response, in 7 patients (70%); and no response, in 1 patient (10%).
      Conclusions: Our study demonstrated that IF-ES therapy can be a promising treatment for the future, is safe, and can benefit from appropriate clinical trials in carefully selected groups. IF-ES therapy is expected to be a safe and effective treatment modality for children with enuresis.

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      참고문헌 (Reference)

      1 Lordêlo P, "Treatment of non-monosymptomatic nocturnal enuresis by transcutaneous parasacral electrical nerve stimulation" 6 : 486-489, 2010

      2 de Oliveira LF, "Transcutaneous parasacral electrical neural stimulation in children with primary monosymptomatic enuresis: a prospective randomized clinical trial" 190 : 1359-1363, 2013

      3 Kajbafzadeh AM, "Transcutaneous interferential electrical stimulation for management of neurogenic bowel dysfunction in children with myelomeningocele" 27 : 453-458, 2012

      4 Lordelo P, "Transcutaneous electrical nerve stimulation in children with overactive bladder: a randomized clinical trial" 184 : 683-689, 2010

      5 Satter EK, "Third-degree burns incurred as a result of interferential current therapy" 30 : 281-283, 2008

      6 Petrofsky J, "The transfer of current through skin and muscle during electrical stimulation with sine, square, Russian and interferential waveforms" 33 : 170-181, 2009

      7 Lindström S, "The neurophysiological basis of bladder inhibition in response to intravaginal electrical stimulation" 129 : 405-410, 1983

      8 Elmissiry M, "Refractory enuresis in children and adolescents: how can urodynamics affect management and what is the optimum test?" 9 : 348-352, 2013

      9 Chase J, "Pilot study using transcutaneous electrical stimulation (interferential current) to treat chronic treatment-resistant constipation and soiling in children" 20 : 1054-1061, 2005

      10 Hoebeke P, "Percutaneous electrical nerve stimulation in children with therapy resistant nonneuropathic bladder sphincter dysfunction: a pilot study" 168 : 2605-2607, 2002

      1 Lordêlo P, "Treatment of non-monosymptomatic nocturnal enuresis by transcutaneous parasacral electrical nerve stimulation" 6 : 486-489, 2010

      2 de Oliveira LF, "Transcutaneous parasacral electrical neural stimulation in children with primary monosymptomatic enuresis: a prospective randomized clinical trial" 190 : 1359-1363, 2013

      3 Kajbafzadeh AM, "Transcutaneous interferential electrical stimulation for management of neurogenic bowel dysfunction in children with myelomeningocele" 27 : 453-458, 2012

      4 Lordelo P, "Transcutaneous electrical nerve stimulation in children with overactive bladder: a randomized clinical trial" 184 : 683-689, 2010

      5 Satter EK, "Third-degree burns incurred as a result of interferential current therapy" 30 : 281-283, 2008

      6 Petrofsky J, "The transfer of current through skin and muscle during electrical stimulation with sine, square, Russian and interferential waveforms" 33 : 170-181, 2009

      7 Lindström S, "The neurophysiological basis of bladder inhibition in response to intravaginal electrical stimulation" 129 : 405-410, 1983

      8 Elmissiry M, "Refractory enuresis in children and adolescents: how can urodynamics affect management and what is the optimum test?" 9 : 348-352, 2013

      9 Chase J, "Pilot study using transcutaneous electrical stimulation (interferential current) to treat chronic treatment-resistant constipation and soiling in children" 20 : 1054-1061, 2005

      10 Hoebeke P, "Percutaneous electrical nerve stimulation in children with therapy resistant nonneuropathic bladder sphincter dysfunction: a pilot study" 168 : 2605-2607, 2002

      11 Moffatt ME, "Nocturnal enuresis: psychologic implications of treatment and nontreatment" 114 (114): 697-704, 1989

      12 Queralto M, "Interferential therapy: a new treatment for slow transit constipation. a pilot study in adults" 15 : e35-e39, 2013

      13 Ford KS, "Full-thickness burn formation after the use of electrical stimulation for rehabilitation of unicompartmental knee arthroplasty" 20 : 950-953, 2005

      14 Kang SH, "Extracorporeal magnetic innervation therapy in children with refractory monosymptomatic nocturnal enuresis" 70 : 576-580, 2007

      15 Neveus T, "Evaluation of and treatment for monosymptomatic enuresis: astandardization document from the International Children’s Continence Society" 183 : 441-447, 2010

      16 Franco I, "Evaluation and treatment of nonmonosymptomatic nocturnal enuresis: a standardization document from the International Children’s Continence Society" 9 : 234-243, 2013

      17 Barroso U Jr, "Electrical stimulation for lower urinary tract dysfunction in children: a systematic review of the literature" 30 : 1429-1436, 2011

      18 Oh-Oka H, "Efficacy on interferential low frequency therapy for elderly overactive bladder patients with urinary incontinence" 98 : 547-551, 2007

      19 Kajbafzadeh AM, "Efficacy of transcutaneous functional electrical stimulation on urinary incontinence in myelomeningocele: results of a pilot study" 36 : 614-620, 2010

      20 Malm-Buatsi E, "Efficacy of transcutaneous electrical nerve stimulation in children with overactive bladder refractory to pharmacotherapy" 70 : 980-983, 2007

      21 Kajbafzadeh AM, "Effect of pelvic floor interferential electrostimulation on urodynamic parameters and incontinency of children with myelomeningocele and detrusor overactivity" 74 : 324-329, 2009

      22 Dasgupta R, "Changes in brain activity following sacral neuromodulation for urinary retention" 174 : 2268-2272, 2005

      23 Lee SD, "An epidemiological study of enuresis in Korean children" 85 : 869-873, 2000

      24 Emmerson C, "A preliminary study of the effect of interferential therapy on detrusor instability in patients with multiple sclerosis" 33 : 64-65, 1987

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