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1 Gatenby RA, "Why do cancers have high aerobic glycolysis?" 4 : 891-899, 2004
2 Moore JD, "VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells" 5 : 12862-, 2014
3 Vander Heiden MG, "Understanding the Warburg effect : the metabolic require ments of cell proliferation" 324 : 1029-1033, 2009
4 Hitosugi T, "Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism" 44 : 864-877, 2011
5 Kroemer G, "Tumor cell metabolism : Cancer’s Achilles’ heel" 13 : 472-482, 2008
6 Stacpoole PW, "Therapeutic targeting of the pyruvate dehydrogenase complex/pyruvate dehydrogenase kinase(PDC/PDK)axis in cancer" 109 : 11-, 2017
7 Kato M, "Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation : role of disordered phosphorylation loops" 16 : 1849-1859, 2008
8 Guerra-Castellano A, "Structural and functional characterization of phosphomimetic mutants of cytochrome c at threonine 28 and serine 47" 1857 : 387-395, 2016
9 Korotchkina LG, "Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase" 276 : 37223-37229, 2001
10 Jing E, "Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation" 62 : 3404-3417, 2013
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25 Golias T, "Hypoxic repression of pyruvate dehydrogenase activity is necessary for metabolic reprogramming and growth of model tumours" 6 : 1-11, 2016
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