일부 폐금속광산 지역 거주 여성의 요중 비소와 8-hydroxydeoxyguanosine 농도 사이의 관련성

국문 초록 (Abstract)

본 연구는 비소에 대한 만성노출이 의심되는 일부 폐금속광산 주변 지역 주민 중 여성들을 대상으로 요중 비소농도와 산화적 유전자 손상지표인 요중 8-hydroxydeoxyguanosine (8-OHdG) 농도와의 관련성을 평가하기 위해 시행되었다. 충청북도에 위치한 두 폐금속광산 지역 주민 중 여성 165명을 대상으로 요중 비소농도와 요중 8-OHdG의 농도를 측정하고 SPSS 12.0 통계프로그램을 이용하여 분석하였다. 조사 대상자들의 요중 비소농도는 기하평균이 5.65 ㎍/g creatinine으로 나타났으며 요중 비소와 8-OHdG 농도와의 관련성 분석에서는 상관계수 0.399 (p＜0.001)의 유의한 상관성을 보였다. 이러한 관련성은 비소노출 농도가 낮은 경우가 노출농도가 높은 경우에 비해 상대적으로 높은 것으로 나타났다. 본 연구의 결과는 요중 8-OHdG 농도가 저농도의 비소에 만성적으로 노출된 여성에서 산화적 유전자 손상을 평가하는 좋은 지표가 될 수 있음을 시사한다.

다국어 초록 (Multilingual Abstract)

This study examines the relationship between urinary arsenic concentration and urinary 8-hydroxydeoxyguanosine (8-OHdG) concentrations, an index of oxidative DNA damage, among women who live near abandoned metal mines. The sample consisted of 165 residents living near two abandoned metal mines located in Chungbuk Province. Demographic characteristics as well as environmental factors relevant to arsenic exposure were collected through interviews, and urinary arsenic concentrations and urinary 8-OHdG concentrations of the research subjects were measured. The collected data were subsequently analyzed using the statistics program SPSS 12.0. The geometric average of urinary arsenic concentrations among the research subjects was 5.65 ㎍/g creatinine. In a correlation analysis between urinary arsenic and 8-OHdG concentrations, the correlation coefficient was significant (p＜0.001) at 0.399. This study suggests that urinary 8-OHdG concentrations may be a DNA damage marker for chronic arsenic exposure in women.

목차 (Table of Contents)

• 서론
• 재료 및 방법
• 결과
• 고찰
• 감사의 글
• References
• 초록

참고문헌 (Reference)

1 Chung, C. J., "Urinary 8-hydroxydeoxyguanosine and urothelial carcinoma risk in low arsenic exposure area" 226 : 14-21, 2008

2 Oremland, R. S., "The ecology of arsenic" 300 : 939-944, 2003

3 Huang, M., "Risk assessment of low-level cadmium and arsenic on the kidney" 72 : 1493-1498, 2009

4 Florea, A. M., "Occurrence, use and potential toxic effects of metals and metal compounds" 19 : 419-427, 2006

5 Cohen, S. M., "Methylated arsenicals: the implications of metabolism and carcinogenicity studies in rodents to human risk assessment" 36 : 99-133, 2006

6 Kapaj, S., "Human health effects from chronic arsenic poisoning--a review" 41 : 2399-2428, 2006

7 Abernathy, C. O., "Health effects and risk assessment of arsenic" 133 : 1536S-1538S, 2003

8 Pi, J., "Evidence for induction of oxidative stress caused by chronic exposure of Chinese residents to arsenic contained in drinking water" 110 : 331-336, 2002

9 Devesa, V., "Effect of thermal treatments on arsenic species contents in food" 46 : 1-8, 2008

10 Buchet, J. P., "Assessment of exposure to inorganic arsenic following ingestion of marine organisms by volunteers" 66 : 44-51, 1994

11 Singh, N., "Arsenic in the environment: effects on human health and possible prevention" 28 : 359-365, 2007

12 Fulladosa, E., "Adverse effects of organic arsenical compounds towards Vibrio fischeribacteria" 377 : 207-213, 2007

13 Lindbäck, B., "A new commercial method for the enzymatic determination of creatinine in serum and urine evaluated: comparison with a kinetic Jaffé method and isotope dilution-mass spectrometry" 35 : 835-837, 1989

14 Pilger, A., "8-Hydroxy-2'-deoxyguanosine as a marker of oxidative DNA damage related to occupational and environmental exposures" 80 : 1-15, 2006