<B>ABSTRACT</B><P>Investigation into the switch between single-celled and filamentous forms of fungi may provide insights into cell polarity, differentiation, and fungal pathogenicity. At the molecular level, much of this investigati...
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https://www.riss.kr/link?id=A107629155
2009
-
SCI,SCIE,SCOPUS
학술저널
1298-1306(9쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<B>ABSTRACT</B><P>Investigation into the switch between single-celled and filamentous forms of fungi may provide insights into cell polarity, differentiation, and fungal pathogenicity. At the molecular level, much of this investigati...
<B>ABSTRACT</B><P>Investigation into the switch between single-celled and filamentous forms of fungi may provide insights into cell polarity, differentiation, and fungal pathogenicity. At the molecular level, much of this investigation has fallen on two closely related budding yeasts, <I>Candida albicans</I> and <I>Saccharomyces cerevisiae</I>. Recently, the much more distant fission yeast <I>Schizosaccharomyces pombe</I> was shown to form invasive filaments after nitrogen limitation (E. Amoah-Buahin, N. Bone, and J. Armstrong, Eukaryot. Cell 4:1287-1297, 2005) and this genetically tractable organism provides an alternative system for the study of dimorphic growth. Here we describe a second mode of mycelial formation of <I>S. pombe</I>, on rich media. Screening of an <I>S. pombe</I> haploid deletion library identified 12 genes required for mycelial development which encode potential transcription factors, orthologues of <I>S. cerevisiae</I> Sec14p and Tlg2p, and the formin For3, among others. These were further grouped into two phenotypic classes representing different stages of the process. We show that galactose-dependent cell adhesion and actin assembly are both required for mycelial formation and mutants lacking a range of genes controlling cell polarity all produce mycelia but with radically altered morphology.</P>
Cooperative Regulation of ADE3 Transcription by Gcn4p and Bas1p in Saccharomyces cerevisiae