자간전증 임부의 혈청내 산화질소와 혈소판 활성화인자의 변화 = The Changes of Serum Nitric Oxide and Platelet Activating Factor Concentrations in Preeclampsia

다국어 초록 (Multilingual Abstract)

Objective : The aim of this study is to determine whether any association exists between preeclampsia and the maternal serum level of nitric oxide (NO) and platelet activating factor (PAF). Methods : NO concentrations were measured using Stuehr`s method and PAF concentrations were measured with [3H]PAF scintillation proximity assay (SPA) system (Amersham Pharmacia Biotech). Data were analyzed with SAS windows version 6.12, with significance established at p<0.05. Results : The mean (±SD) maternal serum concentrations of NO were significantly higher in the group with severe preeclampsia (5.535±0.343 ug/㎖) and mild preeclampsia (5.891±0.481 ug/㎖) than in the normotensive pregnancy group (2.036±0.744 ug/㎖) (p<0.05). The mean (±SD) maternal serum concentrations of PAF were significantly higher in the group with severe preeclampsia (928.9±32.3 ng/㎖) and mild preeclampsia (789.1±63.9 ng/㎖) than in the normotensive pregnancy group (435.8±59.5 ng/㎖) (p<0.05). The mean birth weight was lower in the mild and severe preeclampsia groups than in the normotensive pregnancy group (p<0.05). Conclusion : Maternal serum NO and PAF concentrations were more increased in preeclampsia than normotensive pregnancy group. NO may therefore serve as compensatory mechanism for vasoconstriction of preeclampsia and PAF as a marker for the risk of preeclampsia.