가토 두개강내압에 대한 Prostaglandins의 효과 = Effects of Prostaglandins on the Intracranial Pressure in Rabbits

국문 초록 (Abstract)

두개강내에 balloon을 넣어 두개강내압을 측정하고 동시에 고동맥(femoral artery)으로 동맥압을 측정하면서 prostaglandins을 포함한 다음 약물에 대한 반응을 고찰하여 다음과 같을 결론을 얻었다.
1) Norepinephrine과 5-HT의 경동맥주입으로 두개강내압은 다같이 상승하였으나 혈압에서 norepinephrine주입시는 비례적으로 상승하고 5-HT주입 시는 하강하였다. Norepinephrine정맥주입시에는 혈압과 두개강내압이 모두 상승하였다.
2) PGA₂와 PGE₂ 동맥 및 정맥주입은 두개강내압을 상승시키나 혈압은 하강시켰다. PGE₁ 동맥주입으로 두개강내압의 일률적 변화는 없으나 혈압은 하강했다.
3) PGF₂α의 동맥주입 및 정맥주입에서 모두 두개강내압은 하강하고 혈압은 약간 상승하였다.

다국어 초록 (Multilingual Abstract)

To understand the pathophysiology of the intracranial pressure changes, the Monro-Kellie-doctrine has been to be a useful concept.
By recent reports it has possibly been suggested that prostaglandins may pathophysiologically contribute to the inherent response of intractranial pressure. Although the cardiovascular effects of several prostaglandins have well been studied, little is known about their effects on cerebral blood vessel and cerebrospinal fluid pressure.
The author observed the effect of prostaglandins injected intra-arterially and intravenously on the intracranial pressure and systemic blood pressure and compared with those of norepinephrine or 5-hydroxytryptamine.
The result were summarized as the follows:
1. The intra-arterial and intravenous injections of a single dose of norepinephrine increased not only the intracrainal pressure but also systemic blood pressure with dose-dependant response.
2. The intra-arterial injection of PGA₂ caused the increase in the intracranial pressure, but on the contrary, the blood pressure was decreased.
The intra-arterial injection of PGE₁ and PGE₂ caused the increase in the intracranial pressure, which was not related to the used doage.
3. The intra-arterial and intravenous injections of PGF₂α decreased the intracranial pressure but increased the blood pressure, both of which were not related to the dosage used.