건선환자에서 피부각질층의 형태학적 변화에 관한 연구 = A Study on the Morphological Changes of Straturm Corneum in Psoriatic Patient

다국어 초록 (Multilingual Abstract)

Psoriasis, which affects 3％ of the outpatients in Republic of Korea, is a common, chronic, recurrent, inflammatory disease of the skin characterized by rounded, circumscribed, erythematous dry scaling patches of various sizes, covered by grayish white or silvery white, imbricated and lamellar scales.
The lesion in ordinary cases have predilectin for the scalp, nails, extensor surfaces of the limbs(especially the shins), the elbows, the knee, and the sacral region.
The histologic picture of psoriasis vulgaris varies considerably with the stage of the lesion and near the margin of advancing plaques. In the fully developed lesions of psoriasis, as best seen at the margin of enlarging plaques, the histologic picture is characterized by
(1) regular elongation of the rete ridges with thickening in their lower portion
(2) elongation and edema of the papillae
(3) thining of the suprapapillary portions of the stratum malpighii, with the occasional presence of granular cells
(4) the absence of granular cells
(5) parakeratosis
(6) the presence of Munro microabscesses
The purpose of this study is to evaluate pathophysiology of psoriasis observing the morphological changes of corneocytes in the epidermis by scanning electron microscope(SEM).
All materials were taken from involved skin of six psoriatic patients, uninvolved skin of six psoriatic patients, six normal persons and treated psoriatic lesions by skin surface biopsy.
The results were as follows :
1. There were no folding lines or microplications in the involved skin of psoriatic patients compared with stratum corneum of normal person.
2. There were more profuse villi and more prominent villous projections in the involved skin than uninvolved skin of psoriatic patients.
3. There were no villi in the corneocytes except a few in normal person.
4. Profuse villi and less prominent villous projections were seen on the treated psoriatic lesions without scales.