A singly charged methyl orange anion(M. O) was found to be extracted with Disopyramide phosphate(DP) as a 1:1 complex in dechloroethane.
MO-dichloroethane system gave a yellow color for DP, while in the absence of DP, an organic phase showed almost n...
A singly charged methyl orange anion(M. O) was found to be extracted with Disopyramide phosphate(DP) as a 1:1 complex in dechloroethane.
MO-dichloroethane system gave a yellow color for DP, while in the absence of DP, an organic phase showed almost no color. In this way, the spectrophotometric method was in vestigated for the determination of DP by soivent extraction.
The results obtained were as follow:
1. The maximum absorption wavelength of the reaction product was 420nm(ε=6.45×10^3.ℓ·moℓ^-1.㎝^-1)
2. Dichloroethane was the best extracting solvent among the several organic solvents and the most suitable pH range was 5.8~6.3
3. Linear relationship was found between absorbance and concentration in the range of 1 x 10^-5M∼10^-4M for DP.
4. This method was suitable for the spectrophotometric determination of DP in mixed pharmaceutical preparation.