The effect of the tumor promoter 12-0-tetradecanoyl-phorbol-13-acetate on the lipid metabolism of rabbit kidney cells was studied. Modification accompanying the phorbol ester-induced differentiation include an increase in the amount of neutral glycero...
The effect of the tumor promoter 12-0-tetradecanoyl-phorbol-13-acetate on the lipid metabolism of rabbit kidney cells was studied. Modification accompanying the phorbol ester-induced differentiation include an increase in the amount of neutral glycerolipids, and a selective incorporation of long-chain fatty alcohols into triacyglycerols and ether-linked akyldiacylglycerols. There is a possibility that the commitment of cells toward inhibition of differentiation characteristics depends on the predisposition of the cells for alteration in lipid metabolism caused by 12-0-tetradecanoylphorbol-13-acetate.