Ginsenosides from Korean red ginseng modulate T cell function via the regulation of NF-AT-mediated IL-2 production

다국어 초록 (Multilingual Abstract)

Korean red ginseng is a traditional health foodfrequently used to prevent or treat various diseasesworldwide. In this study, we evaluated the immunomodulatoryactivities of eleven compounds (1–11) isolated fromKorean red ginseng, focusing on T cell function. First, theeffects of the eleven compounds were studied on the regulationof IL-2, a potent T cell growth factor. Compounds5, 7, and 9 significantly increased IL-2 secretion in phorbol12-myristate 13-acetate (PMA)/ionomycin (Io)-inducedEL-4 T cells. Next, we examined the effects of compounds5, 7, and 9 on the regulation of transcription factors relatedto IL-2 production in T cells. Compound 9 significantlyincreased the PMA/Io-induced promoter activity of nuclearfactor of activated T cells (NF-AT) in EL-4 T cells, but didnot have any significant effects on the promoters of NFjB.
These results suggest that compound 9 activates T cellfunction via the regulation of NF-AT-mediated IL-2production.

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