목적: 골 견인 시 견인율에 따라 성장인자가 근육 재생에 미치는 영향을 평가하였다. 대상 및 방법: 골 견인이 쥐의 전 경골근과 가자미 근에 미치는 영향을 측정했다. 성장 인자로 IGF-I, PDG...
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https://www.riss.kr/link?id=A76171832
2006
Korean
KCI등재
학술저널
1028-1036(9쪽)
1
0
상세조회0
다운로드국문 초록 (Abstract)
목적: 골 견인 시 견인율에 따라 성장인자가 근육 재생에 미치는 영향을 평가하였다. 대상 및 방법: 골 견인이 쥐의 전 경골근과 가자미 근에 미치는 영향을 측정했다. 성장 인자로 IGF-I, PDG...
목적: 골 견인 시 견인율에 따라 성장인자가 근육 재생에 미치는 영향을 평가하였다.
대상 및 방법: 골 견인이 쥐의 전 경골근과 가자미 근에 미치는 영향을 측정했다. 성장 인자로 IGF-I, PDGF, 그리고 bFGF를 사용하였고, 6개월 된 Sprague-Dawley 쥐를 사용했다. 오른쪽 경골을 견인시켰고, 왼쪽 경골을 대조군으로 각각 6마리씩 신연율 0.35 ㎜/day인 군과 신연율 0.7 ㎜/day인 군으로 나누었다.
결과: 전 경골 근에서, IGF-I 발현이 신연한 군에서 증가하였고(p<0.001), 신연율 0.7 ㎜/day인 군에서 신연율 0.35 ㎜/day인 군보다 감소하였지만(p<0.01), 가자미 근에서는 유의성이 없었다(p>0.05). PDGF 발현은 전 경골근에서 신연율이 0.7 ㎜/day인 군이 신연율 0.35 ㎜/day인 군보다 증가했지만 유의성은 없었다(p=0.145). 가자미 근에서 신연율 0.7 ㎜/day인 군이 신연율 0.35 ㎜/day인 군보다 감소했지만 유의성은 없었다(p>0.05). bFGF의 발현은 전 경골근과 가자미근에서 신연율이 0.7 ㎜/day인 군과 신연율 0.35 ㎜/day인 군에서 모두 발현하지 않았다.
결론: 골 견인은 성장인자 분비를 증가시키나 성숙된 근육에서 성장인자의 분비는 신연율에 따라 감소한다. Myosatellite 세포에서 IGF-I과 PDGF가 발현되는 것을 관찰되었으며 bFGF가 전 그룹에서 발현되지 않으므로 bFGF가 골세포의 증식과 성장에는 매우 중요한 역할을 하나 신연 골 연장술 시 골격근 세포의 성장에 관여하지 않거나 의미가 없는 것으로 판단되었다.
다국어 초록 (Multilingual Abstract)
Purpose : This study evaluated the influence of growth factors on muscle regeneration when the bone is distracted, relative to the distraction rate. Materials and Methods : The influence of bone distraction on the tibialis anterior and soleus muscl...
Purpose : This study evaluated the influence of growth factors on muscle regeneration when the bone is distracted, relative to the distraction rate.
Materials and Methods : The influence of bone distraction on the tibialis anterior and soleus muscles of 6-month-old Sprague-Dawley rats was evaluated. IGF-I, PDGF, and bFGF expression were used as growth markers. The rats were divided into two groups containing six rats each. In each group, the right tibia was distracted and the left tibia was used as the control. The distraction rates were 0.35 and 0.7 ㎜/day in the respective groups.
Results : For the tibialis anterior, the level of IGF-I expression in the group distracted at 0.35 ㎜/day was significantly higher (p<0.001) but significantly lower (p<0.01) in the group distracted at 0.7 ㎜/day than in the control. In contrast, there was no significant change in the soleus muscle (p>0.05). In the tibialis anterior, PDGF expression was higher in the group distracted at 0.7 mm/day but this increase was not significant (p=0.145). In the soleus, the expression level was lower in the group distracted at 0.7 ㎜/day but the difference was not significant (p>0.05). bFGF was not expressed in the tibialis anterior or soleus.
Conclusion : Bone distraction promotes the release of growth factors but the amount of growth factor released in mature muscle decreases in proportion to the distraction rate. bFGF is not related to myoblast proliferation and differentiation. Moreover, the amount of muscle growth decreases with increasing rate of muscle distraction.
참고문헌 (Reference)
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1 "and complications of limb lengthening by the Ilizarov technique" 81-104, 1990
2 "Viral mediated expression of insulin-like growth factor I blocks the aging-related loss of skeletal muscle function" 95 : 15603-15607, 1998
3 "Towards understanding skeletal muscle regeneration" 187 : 1-22, 1991
4 "The effect of fibroblast growth factor-2 on the osteinductive activity of recombinant human bone morphogenetic protein-2 in rat muscle" 47 : 577-584, 2002
5 "The biology of platelet-derived growth factor" 156-169, 1986
6 "The adaptation of perimuscular connective tissue during distraction osteogenesis" 379 : 259-269, 2000
7 "Sequential immunohistochemical expression of IGF-1 and the transferrin receptor in regenerating rat muscle in vivo" 733-738, 1989
8 "Satellite cell proliferative compartments in growing skeletal muscles" 175 : 84-94, 1996
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10 "Regulation of skeletal alpha-actin promoter in young chickens during hypertrophy caused by stretch overload" 268 : 918-924, 1995
11 "Regenerating skeletal muscle cells express insulin-like growth factor 1" 130 : 327-332, 1987
12 "Rat model of distraction osteogenesis" 15 : 221-226, 1997
13 "Platelet-derived growth factor promotes division and motility and inhibits premature differentiation of the oligodendrocyte/type-2 astrocyte progenitor cell" 333 : 560-562, 1988
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상완골 두 치환술을 이용한 회전근 개 파열 관절증의 치료
제한적 수근골 유합술을 이용한 Kienböck 질환의 치료
원위 요골의 부정 유합으로 인한 원위 요척 관절에서의 척골 두와 요골 간의 위치 변화
학술지 이력
연월일 | 이력구분 | 이력상세 | 등재구분 |
---|---|---|---|
2026 | 평가예정 | 재인증평가 신청대상 (재인증) | |
2020-04-14 | 학회명변경 | 영문명 : 미등록 -> The Korean Orthopaedic Association | |
2020-01-01 | 평가 | 등재학술지 유지 (재인증) | |
2017-01-01 | 평가 | 등재학술지 유지 (계속평가) | |
2014-01-14 | 학술지명변경 | 외국어명 : 미등록 -> Journal of the Korean Orthopaedic Association | |
2013-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2010-01-01 | 평가 | 등재 1차 FAIL (등재유지) | |
2008-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2005-05-30 | 학술지등록 | 한글명 : 대한정형외과학회지외국어명 : 미등록 | |
2005-01-01 | 평가 | 등재학술지 선정 (등재후보2차) | |
2004-01-01 | 평가 | 등재후보 1차 PASS (등재후보1차) | |
2002-07-01 | 평가 | 등재후보학술지 선정 (신규평가) |
학술지 인용정보
기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
---|---|---|---|
2016 | 0.06 | 0.06 | 0.08 |
KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
0.08 | 0.08 | 0.24 | 0.01 |