Ginkgolide B 유도체인 SKI 5051의 항 혈소판 응집작용 = The Antiplatelet Aggregating Effect of a Derivative of Ginkgolide B, SKI 5051, in vitro and in vivo

다국어 초록 (Multilingual Abstract)

This study was performed to test the antiplatelet aggregating effect of a derivative of Ginkgolide B(SKI 5051) alone and with calcium antagonist and aspirin on the mouse pulmonary thromboembolism and collagen-induced rabbit platelet aggregation.
Ginkgolide B is a potent PAF antagonist, which was isolated from the leaves of Ginkgo biloba and 10' -(3,5-Dimethylpyridine-2-methoxy) Ginkgolide B(SKI 5051) is a derivative of Ginkgokide B.
A derivative of Ginkgolide B(SKI 5051) protected mice from sudden death by collagen and epinephrine mixture and inhibited collagen-induced rabbit platelet aggregation dose-dependently. These effects increased by concurrent administration with aspirin and verapamil.
These results suggest that a derivative of Ginkgolide B(SKI 5051) is a effective drug for preventing disease associated with platelet aggregation and this effect is increased by concurrent administration with calcium antagonist and aspirin.