1 Kim T, "p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2" 208 : 875-883, 2011
2 Kim NH, "p53 and microRNA-34 are suppressors of canonical Wnt signaling" 4 : 71-, 2011
3 Siemens H, "miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions" 10 : 4256-4271, 2011
4 Fodde R, "Wnt/beta-catenin signaling in cancer stemness and malignant behavior" 19 : 150-158, 2007
5 Yook JI, "Wnt-dependent regulation of the E-cadherin repressor snail" 280 : 11740-11748, 2005
6 Basset-Seguin N, "Vismodegib in patients with advanced basal cell carcinoma(STEVIE) : a preplanned interim analysis of an international, open-label trial" 16 : 729-736, 2015
7 Thornton K, "Vandetanib for the treatment of symptomatic or progressive medullary thyroid cancer in patients with unresectable locally advanced or metastatic disease : U. S. Food and Drug Administration drug approval summary" 18 : 3722-3730, 2012
8 Chau NG, "Vandetanib for the treatment of medullary thyroid cancer" 19 : 524-529, 2013
9 Bennasroune A, "Tyrosine kinase receptors as attractive targets of cancer therapy" 50 : 23-38, 2004
10 Figueroa-Magalhaes MC, "Treatment of HER2-positive breast cancer" 23 : 128-136, 2014
11 Polyak K, "Transitions between epithelial and mesenchymal states : acquisition of malignant and stem cell traits" 9 : 265-273, 2009
12 Savagner P, "The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition" 137 : 1403-1419, 1997
13 Spaderna S, "The transcriptional repressor ZEB1promotes metastasis and loss of cell polarity in cancer" 68 : 537-544, 2008
14 Moody SE, "The transcriptional repressor Snail promotes mammary tumor recurrence" 8 : 197-209, 2005
15 Batlle E, "The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells" 2 : 84-89, 2000
16 Cano A, "The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression" 2 : 76-83, 2000
17 Aigner K, "The transcription factor ZEB1(deltaEF1)promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity" 26 : 6979-6988, 2007
18 Vandewalle C, "The role of the ZEB family of transcription factors in development and disease" 66 : 773-787, 2009
19 Wang Z, "The role of Notch signaling pathway in epithelial-mesenchymal transition(EMT)during development and tumor aggressiveness" 11 : 745-751, 2010
20 Gregory PA, "The miR-200family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1" 10 : 593-601, 2008
21 Korpal M, "The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2" 283 : 14910-14914, 2008
22 Briscoe J, "The mechanisms of Hedgehog signalling and its roles in development and disease" 14 : 416-429, 2013
23 White PT, "The discovery and development of sorafenib for the treatment of thyroid cancer" 10 : 427-439, 2015
24 Hajra KM, "The SLUG zinc-finger protein represses E-cadherin in breast cancer" 62 : 1613-1618, 2002
25 Tauriello DVF, "TGFbeta drives immune evasion in genetically reconstituted colon cancer metastasis" 554 : 538-543, 2018
26 Mariathasan S, "TGFbeta attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells" 554 : 544-554, 2018
27 Lamouille S, "TGF-beta-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion" 125 : 1259-1273, 2012
28 Akhurst RJ, "TGF-beta signaling in cancer—a double-edged sword" 11 : S44-S51, 2001
29 Katsuno Y, "TGF-beta signaling and epithelial-mesenchymal transition in cancer progression" 25 : 76-84, 2013
30 Bhola NE, "TGF-beta inhibition enhances chemotherapy action against triple-negative breast cancer" 123 : 1348-1358, 2013
31 Valcourt U, "TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition" 16 : 1987-2002, 2005
32 Franci C, "Snail1 protein in the stroma as a new putative prognosis marker for colon tumours" 4 : e5595-, 2009
33 Li X, "Snail induction is an early response to Gli1that determines the efficiency of epithelial transformation" 25 : 609-621, 2006
34 Come C, "Snail and slug play distinct roles during breast carcinoma progression" 12 : 5395-5402, 2006
35 Fendrich V, "Snail and Sonic Hedgehog activation in neuroendocrine tumors of the ileum" 14 : 865-874, 2007
36 Zhang X, "Snail and Axin2 expression predict the malignant transformation of oral leukoplakia" 73 : 48-55, 2017
37 Chang TH, "Slug confers resistance to the epidermal growth factor receptor tyrosine kinase inhibitor" 183 : 1071-1079, 2011
38 Derynck R, "Signaling pathway cooperation in TGF-beta-induced epithelial-mesenchymal transition" 31 : 56-66, 2014
39 Gonzalez DM, "Signaling mechanisms of the epithelial-mesenchymal transition" 7 : re8-, 2014
40 Spigel DR, "Results from the phase III randomized trial of onartuzumab plus erlotinib versus erlotinib in previously treated stage IIIB or IV non-smallcell lung cancer : METLung" 35 : 412-420, 2017
41 Witta SE, "Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines" 66 : 944-950, 2006
42 Craene BD, "Regulatory networks defining EMT during cancer initiation and progression" 13 : 97-, 2013
43 Hsu DS, "Regulation of excision repair cross-complementation group 1 by Snail contributes to cisplatin resistance in head and neck cancer" 16 : 4561-4571, 2010
44 Rizzo P, "Rational targeting of Notch signaling in cancer" 27 : 5124-5131, 2008
45 Spigel DR, "Randomized phase II trial of Onartuzumab in combination with erlotinib in patients with advanced non-small-cell lung cancer" 31 : 4105-4114, 2013
46 Yoshida T, "RECIST progression patterns during EGFR tyrosine kinase inhibitor treatment of advanced non-small cell lung cancer patients harboring an EGFR mutation" 90 : 477-483, 2015
47 Hoffman LM, "Phase I trial of weekly MK-0752 in children with refractory central nervous system malignancies : a pediatric brain tumor consortium study" 31 : 1283-1289, 2015
48 Simonelli M, "Phase I study of PF-03446962, a fully human monoclonal antibody against activin receptor-like kinase-1, in patients with hepatocellular carcinoma" 27 : 1782-1787, 2016
49 Morris JC, "Phase I study of GC1008 (fresolimumab): a human anti-transforming growth factor-beta (TGFbeta) monoclonal antibody in patients with advanced malignant melanoma or renal cell carcinoma" 9 : e90353-, 2014
50 Krop I, "Phase I pharmacologic and pharmacodynamic study of the gamma secretase(Notch)inhibitor MK-0752 in adult patients with advanced solid tumors" 30 : 2307-2313, 2012
51 Lee SM, "Phase 2 study of RO4929097, a gamma-secretase inhibitor, in metastatic melanoma : SWOG 0933" 121 : 432-440, 2015
52 Ikeda M, "Phase 1b study of galunisertib in combination with gemcitabine in Japanese patients with metastatic or locally advanced pancreatic cancer" 79 : 1169-1177, 2017
53 Mayo C, "Pharmacogenetics of EGFR in lung cancer: perspectives and clinical applications" 13 : 789-802, 2012
54 Tuhkanen H, "Nuclear expression of Snail1 in borderline and malignant epithelial ovarian tumours is associated with tumour progression" 9 : 289-, 2009
55 Sahlgren C, "Notch signaling mediates hypoxia-induced tumor cell migration and invasion" 105 : 6392-6397, 2008
56 Caglevic C, "Nintedanib in non-small cell lung cancer : from preclinical to approval" 9 : 164-172, 2015
57 Ahn SY, "Niclosamide is a potential therapeutic for familial adenomatosis polyposis by disrupting axin-GSK3 interaction" 8 : 31842-31855, 2017
58 Eisenhauer EA, "New response evaluation criteria in solid tumours : revised RECIST guideline(version 1. 1)" 45 : 228-247, 2009
59 Kang JS, "New regulatory mechanisms of TGF-beta receptor function" 19 : 385-394, 2009
60 Lustig B, "Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors" 22 : 1184-1193, 2002
61 Lamouille S, "Molecular mechanisms of epithelial-mesenchymal transition" 15 : 178-196, 2014
62 Chaffer CL, "Mesenchymal to epithelial transition in development and disease" 185 : 7-19, 2007
63 Graham TR, "Insulinlike growth factor-I-dependent up-regulation of ZEB1 drives epithelial-to-mesenchymal transition in human prostate cancer cells" 68 : 2479-2488, 2008
64 Arend RC, "Inhibition of Wnt/beta-catenin pathway by niclosamide : a therapeutic target for ovarian cancer" 134 : 112-120, 2014
65 Anderton MJ, "Induction of heart valve lesions by small-molecule ALK5 inhibitors" 39 : 916-924, 2011
66 Zoli W, "In vitro preclinical models for a rational design of chemotherapy combinations in human tumors" 37 : 69-82, 2001
67 Fan W, "In vitro evaluation of combination chemotherapy against human tumor cells(Review)" 5 : 1035-1042, 1998
68 Chockley PJ, "Immunological consequences of epithelial-mesenchymal transition in tumor progression" 197 : 691-698, 2016
69 Gupta PB, "Identification of selective inhibitors of cancer stem cells by high-throughput screening" 138 : 645-659, 2009
70 Yang Q, "Idelalisib : first-in-class PI3K delta inhibitor for the treatment of chronic lymphocytic leukemia, small lymphocytic leukemia, and follicular lymphoma" 21 : 1537-1542, 2015
71 Grotegut S, "Hepatocyte growth factor induces cell scattering through MAPK/Egr-1-mediated upregulation of Snail" 25 : 3534-3545, 2006
72 Moreno-Bueno G, "Genetic profiling of epithelial cells expressing E-cadherin repressors reveals a distinct role for Snail, Slug, and E47 factors in epithelial-mesenchymal transition" 66 : 9543-9556, 2006
73 Rodon J, "First-in-human dose study of the novel transforming growth factor-beta receptor I kinase inhibitor LY2157299 monohydrate in patients with advanced cancer and glioma" 21 : 553-560, 2015
74 Lang L, "FDA approves sorafenib for patients with inoperable liver cancer" 134 : 379-, 2008
75 Vogelzang NJ, "Everolimus vs. temsirolimus for advanced renal cell carcinoma : use and use of resources in the US Oncology Network" 11 : 115-120, 2013
76 Murphy M, "Erlotinib or gefitinib for the treatment of relapsed platinum pretreated non-small cell lung cancer and ovarian cancer : a systematic review" 14 : 177-190, 2011
77 Marcucci F, "Epithelial–mesenchymal transition : a new target in anticancer drug discovery" 15 : 311-, 2016
78 Thiery JP, "Epithelialmesenchymal transitions in development and disease" 139 : 871-890, 2009
79 Thiery JP, "Epithelial-mesenchymal transitions in tumour progression" 2 : 442-454, 2002
80 Kalluri R, "Epithelial-mesenchymal transition and its implications for fibrosis" 112 : 1776-1784, 2003
81 Arumugam T, "Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer" 69 : 5820-5828, 2009
82 Kuczynski EA, "Effects of sorafenib dose on acquired reversible resistance and toxicity in hepatocellular carcinoma" 75 : 2510-2519, 2015
83 Shah MA, "Effect of Fluorouracil, leucovorin, and oxaliplatin with or without onartuzumab in HER2-negative, MET-positive gastroesophageal adenocarcinoma : the METGastric randomized clinical trial" 3 : 620-627, 2017
84 Park CY, "EW-7203, a novel small molecule inhibitor of transforming growth factor-beta(TGFbeta)type I receptor/activin receptor-like kinase-5, blocks TGFbeta1-mediated epithelial-to-mesenchymal transition in mammary epithelial cells" 102 : 1889-1896, 2011
85 Son JY, "EW-7197, a novel ALK-5 kinase inhibitor, potently inhibits breast to lung metastasis" 13 : 1704-1716, 2014
86 Sanchez-Tillo E, "EMTactivating transcription factors in cancer : beyond EMT and tumor invasiveness" 69 : 3429-3456, 2012
87 Nieto MA, "EMT: 2016" 166 : 21-45, 2016
88 Haslehurst AM, "EMT transcription factors snail and slug directly contribute to cisplatin resistance in ovarian cancer" 12 : 91-, 2012
89 Tryndyak VP, "E-cadherin transcriptional down-regulation by epigenetic and microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells" 126 : 2575-2583, 2010
90 Lu Z, "Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion" 4 : 499-515, 2003
91 Kroepil F, "Downregulation of CDH1 is associated with expression of SNAI1 in colorectal adenomas" 7 : e46665-, 2012
92 Irie HY, "Distinct roles of Akt1and Akt2 in regulating cell migration and epithelial-mesenchymal transition" 171 : 1023-1034, 2005
93 Wilhelm S, "Discovery and development of sorafenib : a multikinase inhibitor for treating cancer" 5 : 835-844, 2006
94 Lacouture ME, "Cutaneous keratoacanthomas/squamous cell carcinomas associated with neutralization of transforming growth factor beta by the monoclonal antibody fresolimumab(GC1008)" 64 : 437-446, 2015
95 Kim HJ, "Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-kappaB and snail" 27 : 3165-3175, 2007
96 Imai K, "Comparing antibody and small-molecule therapies for cancer" 6 : 714-727, 2006
97 Zhang W, "Chemoresistance to 5-fluorouracil induces epithelial-mesenchymal transition via up-regulation of Snail in MCF7human breast cancer cells" 417 : 679-685, 2012
98 Lamouille S, "Cell size and invasion in TGF-betainduced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway" 178 : 437-451, 2007
99 Wu ZQ, "Canonical Wnt signaling regulates Slug activity and links epithelial-mesenchymal transition with epigenetic breast cancer 1, early onset(BRCA1)repression" 109 : 16654-16659, 2012
100 Zhu Y, "Biological and clinical significance of cancer stem cell plasticity" 3 : 32-, 2014
101 Wieland A, "Anticancer effects of niclosamide in human glioblastoma" 19 : 4124-4136, 2013
102 Bezdekova M, "Analysis of Snail-1, E-cadherin and claudin-1expression in colorectal adenomas and carcinomas" 13 : 1632-1643, 2012
103 Hay ED, "An overview of epithelio-mesenchymal transformation" 154 : 8-20, 1995
104 Park CY, "An novel inhibitor of TGF-beta type I receptor, IN-1130, blocks breast cancer lung metastasis through inhibition of epithelial-mesenchymal transition" 351 : 72-80, 2014
105 Xie L, "Activation of the Erk pathway is required for TGF-beta1-induced EMT in vitro" 6 : 603-610, 2004
106 Pattabiraman DR, "Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumorinitiating ability" 351 : aad3680-, 2016
107 Yochum GS, "AXIN2: tumor suppressor, oncogene or both in colorectal cancer?" 4 : 7-8, 2012
108 Spaderna S, "A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer" 131 : 830-840, 2006
109 De Jesus-Acosta A, "A phase II study of the gamma secretase inhibitor RO4929097 in patients with previously treated metastatic pancreatic adenocarcinoma" 32 : 739-745, 2014
110 Diaz-Padilla I, "A phase II study of single-agent RO4929097, a gamma-secretase inhibitor of Notch signaling, in patients with recurrent platinumresistant epithelial ovarian cancer : a study of the Princess Margaret, Chicago and California phase II consortia" 137 : 216-222, 2015
111 Strosberg JR, "A phase II study of RO4929097 in metastatic colorectal cancer" 48 : 997-1003, 2012
112 Wheatley-Price P, "A phase II study of PF-03446962 in patients with advanced malignant pleural mesothelioma. CCTG Trial IND. 207" 11 : 2018-2021, 2016
113 Brandes AA, "A phase II randomized study of galunisertib monotherapy or galunisertib plus lomustine compared with lomustine monotherapy in patients with recurrent glioblastoma" 18 : 1146-1156, 2016
114 Goff LW, "A phase I study of the anti-activin receptor-like kinase 1(ALK-1)monoclonal antibody PF-03446962 in patients with advanced solid tumors" 22 : 2146-2154, 2016
115 Bracken CP, "A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition" 68 : 7846-7854, 2008
116 Yook JI, "A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells" 8 : 1398-1406, 2006
117 Vincent T, "A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition" 11 : 943-950, 2009