Usefulness of Ultrasound in the Evaluation of Morphologic Change of a Cirrhotic Liver During Respiration

다국어 초록 (Multilingual Abstract)

Purpose: This study was designed to determine whether transabdominal ultrasound can detect different hepatic stiffness between patients with cirrhosis and control subjects.
Materials and Methods: Sevent-three patients (Child-Pugh class A stage) with liver cirrhosis and 57 control subjects were included in this study. All patients were subdivided arbitrarily into two groups: early cirrhosis (n = 53) and overt cirrhosis (n =20). Two sagittal images of the left lobe of the liver were obtained in the left hepatic vein level during the resting state and at full inspiration while pushing their belly out, by abdominal US (i.e., resting and stress image). The length between the inferior hepatic angle and the midpoint of the liver dome was measured in all images for the evaluation of liver distortion. The elongation was calculated by a formula: (L2-L1/L1) ×100(%); where L1 and L2 are the length of the liver for both the resting and stress image. The calculated elongated length (L2-L1, EL) and elongation rate were compared between cirrhotic patients and control subjects.
Results: For the control subjects, early cirrhosis, and overt cirrhosis groups, the mean ELs (elongation rate) were 2.34±0.98 cm (30.2±13.2%), 1.18±0.73 cm (14.9±9.5%) and 0.53±0.54 cm (6.3±6.6%), respectively. This difference among the three groups was statistically significant (p < 0.05). A possible best cut-off value of liver elongation rate is 17% for the prediction of cirrhosis (sensitivity: 90%, specificity:75.3%).
Conclusion: The liver of patients with liver cirrhosis is stiffer than that of control subjects. Calculation of the elongation rate in the left lobe of the liver during a respiratory maneuver may be used as an ancillary method of US for the evaluation of liver cirrhosis.

참고문헌 (Reference)

1 Goldin RD, "intra-observer and inter-observer variation in the histopathological assessment of chronic viral hepatitis" 25 : 649-654, 1996

2 Sandrin L, "Transient elastography: a new non-invasive method for assessment of hepatic fibrosis" 29 : 1705-1713, 2003

3 Schalm SW, "The diagnosis of cirrhosis: clinical relevance and methodology" 27 : 1118-1119, 1997

4 V Simonovsky, "The diagnosis of cirrhosis by high resolution ultrasound of the liver surface" 72 : 29-34, 1999

5 Tchelepi H, "Sonography of diffuse liver disease" 21 : 1023-1032, 2002

6 Zwiebe WJ, "Sonographic diagnosis of diffuse liver disease" 16 : 8-15, 1995

7 Fraquelli M, "Reproducibility of transient elastography(TE) in assessing hepatic fibrosis" 56 : 968-973, 2007

8 Ferrell LD, "Modern surgical pathology" Saunders 919-979, 2003

9 Konate A, "Liver stiffness measurement by transient elastography: predictive factors of accuracy, success and reproducibility" 44 : S195-S195, 2006

10 Lim AKP, "Hepatic vein transit times using a microbubble agent can predict disease severity non-invasively in patients with hepatitis C" 54 : 128-133, 2005