사람 암세포와 단핵세포에서 고포도당 농도에 의한 FDG 섭취 저하의 서로 다른 기전 = Decreased glucose uptake by hyperglycemia is regulated by different mechanisms in human cancer cells and monocytes

다국어 초록 (Multilingual Abstract)

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다국어 초록 (Multilingual Abstract)

To clarify the difference in glucose uptake between human cancer cells and monocytes, we studied [^18F] fluorodeoxyglucose (FDG) uptake in three human colon cancer cell lines (SNU-C2A, SNU-C4, SNU-C5), one human lung cancer cell line (NCI-H522), and human peripheral blood monocytes. The FDG uptake of both cancer cells and monocytes was increased in glucose-free medium, but decreased in the medium containing 16.7 mM glucose (hyperglycemic). The levelof Glut1 mRNA decreased in human colon cancer cells and NCI-H522 under hyperglycemic condition. Glut1 protein expression was also decreased in the four human cancer cell lines under hyperglycemic condition, whereas it was consistently undetectable in monocytes. SNU-C2A, SNU-C4 and NCI-H522 showed a similar level of hexokinase activity (7.5-10.8mU/mg), while SNU-C5 and monocytes lower range of hexokinase activity (4.3-6.5 mU/mg). These data suggest that glucose uptake is regulated by different mechanisms in human cancar cells and monocytes. (Korean J Nucl Med 2002;36;110-120)