Kikuchi-Fujimoto disease in the right cervical lymph node: a case report & literature review

다국어 초록 (Multilingual Abstract)

Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease, KFD) is a benign self-limiting lesion that can self-heal when no severe symptoms are present. KFD resembles tuberculous lymphadenitis and malignant lymphoma. Thus, early differential diagnosis will minimize unnecessary evaluation and treatment. Histological examination of a lymph node biopsy or fine needle aspiration could be a reliable method for KFD diagnosis. This study reports a case of histiocytic necrotizing lymphadenitis of the right cervical lymph node in a 52-year-old female patient. According to the fine needle aspiration biopsy result, the patient was diagnosed with Kikuchi-Fujimoto disease and treated with prednisolone (15 mg/day). After treatment, there was no recurrence or adverse event.

참고문헌 (Reference)

1 최정우, "아급성 림프절염의 임상·병리학적 분석" 대한병리학회 38 (38): 289-294, 2004

2 Ogawa M, "Ultrasonography of vervical lymphadenopathy in a patient with Kikuchi’s disease" 32 (32): 260-261, 1991

3 Yufu Y1, "Parvovirus B19-associated haemophagocytic syndrome with lymphadenopathy resembling histiocytic necrotizing lymphadenitis(Kikuchi’s disease)" 96 (96): 868-871, 1997

4 Kikuchi M, "Necrotizing lymphadenitis:possible acute toxoplasmic infection" 376 (376): 247-253, 1997

5 Yalcin S, "Management of Kikuchi-Fujimoto disease using glucocorticoid: a case report" 2011 : 230840-, 2011

6 Kikuchi M, "Lymphadenitis showing focal reticulum cell hyperplasia with nuclear debris and phagocytosis" 35 : 379-380, 1972

7 Ramirez AL, "Kikuchi-Fujimoto’s disease:an easily misdiagnosed clinical entity" 125 (125): 651-653, 2001

8 Kucukardali Y1, "Kikuchi-Fujimoto disease: analysis of 244 cases" 26 (26): 50-54, 2007

9 Garcia C, "Kikuchi-Fujimoto disease of the neck" 102 : 11-15, 1993

10 장태화, "Kikuchi-Fujimoto Disease의 치험례" 대한악안면성형재건외과학회 29 (29): 548-553, 2007

11 Tsang WY, "Fine-needle aspiration cytologic diagnosis of Kikuchi’s lymphadenitis. A report of 27 cases" 102 (102): 454-458, 1994

12 Bosch X, "Enigmatic Kikuchi-Fujimoto disease: a comprehensive review" 122 (122): 141-152, 2004

13 Tong TR, "Diagnosing Kikuchi disease on fine needle aspiration biopsy: a retrospective study of 44 cases diagnosed by cytology and 8 by histopathology" 45 (45): 953-957, 2001

14 Hudnall SD, "Detection of human herpesvirus DNA in Kikuchi-Fujimoto disease and reactive lymphoid hyperplasia" 1 (1): 362-368, 2008

15 Song JY, "Clinical outcome and predictive factors of recurrence among patients with Kikuchi’s disease" 13 (13): 322-326, 2009

16 Fujimoto Y, "Cervical subacute necrotizing lymphadenitis" 20 : 920-927, 1972

17 Kwon SY, "CT findings in Kikuchi disease: analysis of 96 cases" 25 (25): 1099-1102, 2004

18 Goldblatt F, "Association of Kikuchi-Fujimoto’s disease with SLE" 47 (47): 553-554, 2008

19 Imamura M, "An ultrastructural study of subacute necrotizing lymphadenitis" 107 (107): 292-299, 1982

20 Huh J, "A study of the viral etiology of histiocytic necrotizing lymphadenitis(Kikuchi-Fujimoto disease)" 13 (13): 27-30, 1998