임신성 고혈압임부에 있어서 혈장내 tumor Necrosis Factor-a 의 의의 = The meaning of serum TNF-a in plasma of patients with severe preeclampsia

다국어 초록 (Multilingual Abstract)

Objective : our purpose was to investigate whether markers for activation of the immune system are present in patients with preeclampsia by assessing maternal plasma for tumor necrosis factor-a. Study design : maternal plasma tumor recrosis factor-a concentrations were measured in nonpregnant women(n=13) women with normal pregnancies (n=8) and women with pregnancies associated with severe preeclampsia (n=15). Tumor necrosis factor-a was measured with enzyme-linked immunoassays. Results : We measured plasma TNF-a level according to preeclmaptic women(n=15), nonpregnant control (n=13) pregnant control (n=8). the median plasma TNF-a levels were 8.53+-21.33, 2.00+-3.92, 7.00+-10.58 respectively. There were no significant difference among three groups. Conclusions : Although there were no significant difference between preeclamptic women, nonpregnant control , pregnant control , Our study showed that TNF-a was detected higher in the plasma of preeclamptic women than in the nonpregnant control and pregnant control. These findings suggest that the pathogenesis of pregnancy induced hypertension is associated with TNF-a , probably.