Improving vaccines by targeting antigens to dendritic cells

다국어 초록 (Multilingual Abstract)

A new approach to enhancing the effectiveness of vaccines
is to deliver antigens selectively to dendritic cells
(DC) in situ, via monoclonal antibodies specific for particular
DC surface molecules. This can markedly enhance
CTL responses and, via helper T cells, also enhance
antibody responses. DC activation agents or adjuvants
must also be administered for effective CTL responses,
but in some cases good antibody responses
can be obtained without adjuvants. Here we review the
role of different DC subsets and different DC target molecules
in obtaining enhanced immune responses.

다국어 초록 (Multilingual Abstract)

A new approach to enhancing the effectiveness of vaccines
is to deliver antigens selectively to dendritic cells
(DC) in situ, via monoclonal antibodies specific for particular
DC surface molecules. This can markedly enhance
CTL responses and, via helper T cells, also enhance
antibody responses. DC activation agents or adjuvants
must also be administered for effective CTL responses,
but in some cases good antibody responses
can be obtained without adjuvants. Here we review the
role of different DC subsets and different DC target molecules
in obtaining enhanced immune responses.

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