中樞神經에 있어 CHLORPROMAZINE이 血壓에 미치는 影響에 關한 實驗的 硏究 = Experimental Studies on the Influences of Chlorpromazine on the Blood Pressure in the Central Nervous System

다국어 초록 (Multilingual Abstract)

Chlorpromazine has many pharmacological actions such as ganglion blocking, antiadrenaline, antiathistamine, antifibrillatory, antipyretic, anticonvaulsant and antiemetic actions. They also showed that chorpromazine enhenced the potency of analgesic and central-depressant drugs.
Despite obvious evidences of an action on the central nervous system, the exact site of action of chlorpromazine has not been determined. It is quite likely that chorpromazine acts on many different potions of the brain.
The hypotensive effects of chlorpromazine have long been recognized. Chlorpromazine can lower the arterial blood pressure through its adreneric blocking activity. Chlorpromazine inhibit the actions of epinephrine and noreponephrine on the blood pressure and can cause epinephrine reversal.
Since chlorpromazine is known to act in a complex manner on the central nervous system, a central mechanism as one component of its hypotensive effect has been postulated by many workers. Depression of the resomotor center by chlorpromazine has been suggested by a number of investigators. Tangri and Bhargava posturlated that both the hypothalamic and the medullary vasomotor areas were depressed by chlopromazine. Bradley believes that chlopromaxeine has a selective action on the sensory inflow into the reticular formation from afferent pathways and he and his colldagues have investigated this action at the neuronal level. It is known that some kind of reciprocal influence exists between the amygdala and the brain stem and also that this influence is probably inhibitory. An interference with this reciprocal relationship could result in a "release" effect and account for the increased activity of the amygdala and hippocampus following administration of chlorpromazine and also for the seizures originating in these regions.
In the study here reported, the effects of chlorpromazine on blood pressure was