Purpose :To determine if the tumor intersitial fluid pressure (TIFP) and/or its change in patients with
metastatic lymph node in head and neck area can predict radiotherapy outcome.
Materials and Methods : In 26 biopsy proven metastatic lymph node p...
Purpose :To determine if the tumor intersitial fluid pressure (TIFP) and/or its change in patients with
metastatic lymph node in head and neck area can predict radiotherapy outcome.
Materials and Methods : In 26 biopsy proven metastatic lymph node patients in head and neck area with accessible by direct inspection and palpation, and of sufficient thickness (> 1 cm) to permit accurate needle placement, we measured TIFP at cervical lymph node before and during radiotherapy. Tumor size was measured clinically and radiologically.
Results :The mean preradiotherapy TIFP was 24.7 mmHg. Preradiotherapy TIFP had marginally significant
relationship with tumor size (p=0.06). Preradiotherapy TIFP significantly decreased when tumor size decreased (p=0.009). Preradiotherapy TIFP was not different between complete response group and group with partial or less respone (p=0.75). Radiotherapy outcome was not different between group with above and group with below than average TIFP (p=0.229). TIFP decreased 36 mmHg in complete response group and 29.7 mmHg in group with partial or less respone.
Conclusion :The mean TIFP was elevated with 24.7 mmHg. Preradiotherapy TIFP had marginally significant relationship with tumor size (p=0.06). TIFP decreased 36 mmHg in complete response group and 29.7 mmHg in group with partial or less respone but there was no statistically significant relationship in two groups.