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KISSUntil recently, central dogma in generics has supported genetic determinism in mechanisms of aging. Since epigenetics is now regarded as another important factor for aging, aging mechanisms cannot be fully explained only by genetic factors. Epigenetic...
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RISS 인기검색어
https://www.riss.kr/link?id=A82448516
- 저자
- 발행기관
- 학술지명
- 권호사항
-
발행연도
2010
-
작성언어
Korean
- 주제어
-
KDC
510
-
자료형태
학술저널
-
수록면
1-8(8쪽)
- 제공처
-
0
상세조회 -
0
다운로드
부가정보
다국어 초록 (Multilingual Abstract)
Until recently, central dogma in generics has supported genetic determinism in mechanisms of aging. Since epigenetics is now regarded as another important factor for aging, aging mechanisms cannot be fully explained only by genetic factors. Epigenetics can be defined as phenotypic changes caused by mechanisms that are not related to changes in DNA sequence itself. Two major mechanisms include DNA methylation and histone modification. In addition, RNA interference, related to all steps of protein production, can also be considered part of epigenetics. Herein we review the genetic and epigenetic mechanisms of aging and focus on the role of epigenetics in aging. Increased understanding of aging process will enable us to prevent and treat age-related diseases.
Until recently, central dogma in generics has supported genetic determinism in mechanisms of aging. Since epigenetics is now regarded as another important factor for aging, aging mechanisms cannot be fully explained only by genetic factors. Epigenetics can be defined as phenotypic changes caused by mechanisms that are not related to changes in DNA sequence itself. Two major mechanisms include DNA methylation and histone modification. In addition, RNA interference, related to all steps of protein production, can also be considered part of epigenetics. Herein we review the genetic and epigenetic mechanisms of aging and focus on the role of epigenetics in aging. Increased understanding of aging process will enable us to prevent and treat age-related diseases.
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인간 배아줄기세포 유래 심근세포의 약물 스크리닝 모델로의 활용에 관한 연구 동향
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