Hemodynamic Evaluation of Acute Mitral Valve Insufficiency Model induced by Chordae Tendinae Rupture in Normal Dogs

다국어 초록 (Multilingual Abstract)

The study was to observe hemodynamic alterations of cardiac function to design a model of canine mitralvalve insufficiency (MVI) based on chordae tendinae rupture (CTR). Ten healthy beagles with normal heart functionwere used in this study. To measure hemodynamics, the patient monitor was equipped for invasive blood pressureand a Swan-Ganz catheter. Hemodynamic alterations were checked promptly during CTR procedures. MVI model wasmade by transection of the chordae tendinae with small arthroscopy hook knife through 5th intercostal open chest.
Color Doppler at the level of the mitral valve showed high-velocity regurgitant flow immediately after CTR atintraoperative echocardiography. In hemodynamic measurements, pulmonary capillary wedge pressure (PCWP) wassignificantly increased, while mean arterial pressure (MAP), venous pressure (VP), pulmonary arterial pressure (PAP),cardiac output (CO) and cardiac index (CI) were significantly decreased after CTR. It was known that the left atriumwas overloaded by regurgitant volume from the left ventricle. In conclusion, the MVI model induced by CTR techniquein this study should be used as suitable one for the effective research of canine mitral valve disease. Further studyshould be needed to measure the chronic alternation of mitral valve in the model.

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