Clinical Significance of Spot Urine Specimen for Urine Collection and an Evaluation of Micro-Bumintest Compared to RIA for Microalbuminuria

다국어 초록 (Multilingual Abstract)

Microalbuminuria may be a useful predictor of nephropathy in diabetes. Moreover, recent interventional studies have demonstrated that intensive insulin regimens may correct the increased albumin excretion in diabetes.
Here we studied to determine whether single void urine samples can be used to estimate 24- hrs excretion and to evaluate the performance of Micro-Bumintest in screening for microalbuminuria in diabetic patients and compared with qualitative RIA determinations of the urinary albumin concentration.
The results were as follows:
1. The overall correlation of spot urine with 24-hrs urine sample results expressed as microgram albumin per milligram creatinine was good (γ =0.54, p=0.0001) and also with 24 hrs urine microalbuminuria was good (γ=0.55, p=0.0001).
2. When 20 ㎍/min (24-hrs albumin excretion) was used as the upper limit of normal, the sensitivity and specificity of Micro-Bumintest in 24-hrs urine specimen were 93.8% and 64.7%.
3. BMI, serum creatinine and microalbuminuria were significantly associated between positive and negative Micro-Bumintest results (p<0.01, p<0.05, p<0.01).
In summary, spot urine specimens are useful in estimating excretion in place of 24-hrs urine collections and the Micro-Bumintest is a reasonable screening method for microalbuminuria.