Postoperative Radiation for Soft Tissue Sarcoma

다국어 초록 (Multilingual Abstract)

To evaluate the role of radiation and chemotherapy after limb-saving operation in the management of soft tissue sarcoma, the authors analysed retrospectively 33 patients treated in Department of Orthopaedic Surgery and Radiation Therapy, Catholic University Medical College, in terms of survival rate, local recurrence and prognostic factors. The sex distribution was 16 males and 17 females. The age distribution ranged from 16 to 81 year old with mean age of 48. The follow-up period ranged from 1 year to 10 years with average of 5.5 years. The histologic diagnoses were 9 liposarcoma(27.2%), 8 MFH(24.2%), 7 unclassifiable(21.2%), 3 rhabdomyosarcoma(9.1%), and 3 fibrosarcoma(9.1%) in orders. While marginal and intralesional margins were gained in 24 patients(72.2%), wide and radical margins were obtained only in 9 patients(27.3%). On postoperative 3 weeks, local irradiation of 5000-7000 cGy was delivered to all patients by shrinking field technique for 5-8 weeks. Of 33 patients, 16(45.5%) patients were recieved adjuvant chemotherapy in combination of adriamycin, cyclophosphamide & vicristine, or VP16 & ifosfamide based on histologic type and obtained surgical margin. The survival rates at 2 years and 5 years were 58% and 37% respectively. Local recurrences occured in 15 patients(45.5%) at average 16 months after operation. In addition, the authors considered surgical margin, presence of local recurrence and tumor size as a significant prognostic factors.