고지방 식이와 병행 섭취한 천마 분말이 흰쥐의 혈청 및 간 조직 지질 함량에 미치는 영향 = Effect of Gastrodiae rhizoma Powder on Serum and Liver Lipid Levels of Rats with High Fat Diet

다국어 초록 (Multilingual Abstract)

This study was performed to study the effects of Gastrodiae rhizoma on lipid concentration of serum and liver in rats fed high fat diet. Male Sprague-Dawley rat were randomly assigned to 5 groups such as basal diet only(BDG), high fat diet(HFG) and high fat diet with 5% processed Gastrodiae rhizoma(GRL), high fat diet with 10% processed Gastrodiae rhizoma(GRM), high fat diet with 15% processed Gastrodiae rhizoma(GRH) supply each of the experimental diets for 6 weeks. Food intake was significantly decreased by both high fat intake and high fat with Gastrodiae rhizoma intake compared with basal diet intake but weight gain was not significantly different from each groups. Liver weights were significantly lowered by Gastrodiae rhizoma intake compared with high fat intake. In the serum, total cholesterol was not significantly different with each groups, but triglyceride level was significantly lowered by Gastrodiae rhizoma intake as compared with control. In the liver, lipid levels inceased with the Gastrodiae rhizoma intake, but total cholesterol and triglyceride levels were not significantly different with control. These results showed that dietary Gastrodiae rhizoma as supplementary food may decrease triglyceride in the serum.

국문 초록 (Abstract)

본 연구는 고지방 식이와 병행 섭취한 천마 분말이 흰쥐의 혈청과 간의 지질 함량에 미치는 영향을 밝히고자 본 연구를 수행하였다. 이에 따라 정상식이군(BDG), 고지방 식이군(HFG), 고지방 식이군에 천마 분말을 각각 5%, 10%, 15% 농도로 첨가한 군(GRL, GRM, GRH)으로 나누어 6주 동안 섭취시킨 결과, 식이 섭취량은 BDG군이 HFG군과 GRL군, GRM군 및 GRH군에 비해 유의적으로 높았으나(p<0.05) 체중 증가량에는 유의적인 차이가 나타나지 않았다. 조직 무게에 있어서 신장과 고환 무게는 유의적 차이가 나타나지 않았으며, 간 조직 무게는 HFG군이 GRL군, GRM군 및 GRH군에 비해 유의적으로 높게 나타났다(p<0.05). 혈청지질 중 총 콜레스테롤 농도는 각 군 간에 유의적인 차이가 없었으며, 혈청 중성지질 농도의 경우 HFG군에 비해 10% 천마 분말을 첨가한 GRM군에서 가장 뚜렷하게 낮아졌다(p<0.05). 혈청 LDL-콜레스테롤 농도는 각 군간 유의적인 차이가 없었으나, AI는 HFG군이 천마 분말첨가군보다 유의적으로 낮았으며(p<0.05), 반면 HTR은 HFG군은 GRL군, GRM군 및 GRH군과 비교할 때 높은 값을 나타났다. 간 조직의 총 지질 함량은 증가된 반면, 총 콜레스테롤 농도와 중성지질 농도는 각 군 간의 유의적인 차이나 나타나지 않았고, 간 조직의 해부학적 차이는 나타나지 않았다. 이러한 결과는 식품첨가물로써 천마식이가 혈청에서 중성지질을 저하시킬 것으로 기대된다.

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