이황화탄소 폭로중단후 기존 건강장해의 진행성에 관한 연구 : 다발성 말초 신경염 및 안저장해를 중심으로 In Cases of Peripheral Polyneuritis and Retinal Change = Study on the Progression of Biological Effects of Workers Following Termination of CS₂Exposure

다국어 초록 (Multilingual Abstract)

The object of this study was to evaluate the possibility of new development of polyneuropathy and microaneurysm in fundus in workers who did not have polyneuropathy and microaneurysm in fundus in the electromyogram(EMG) and ophthalmoscopic examination. The total number of subjects was 144 workers who had the EMG and funduscopic examination done at least twice. There were kinds of subjects. The one of subjects was a total of 120 workers who were examined at least twice in their annual health examination for carbon disulfide poisoning. The other subjects were a total of 24 volunteer workers who worked in the rayon manufacturing factory. The results were as follows:
1. There was no cases of polyneuropathy or microaneurysm in volunteers.
2. The new cases of polyneuropathy were detected in 12 (14.3%) out of 84 subjects, and those of microaneurysm in fundus were detected in 30 (26.5%) out of 113 subjects.
3. We investigated the variables showing difference between the new cases and other cases who had no polyneuropathy or microaneurysm in fundus in repeated examinations. The both of polyneuropathy or microaneurysm cases had higher cummulative exposure index, and most of them were workers in the department of spinning where the concentration of cs₂in air was highest in the rayon manufacturing company.
4. There were no statistically significant variables by logistic regression analysis in the polyneuropathy cases. The cummulative index and the department were the statistically significant variable in the development of microaneurysm.
5. Above findings showed that workers who had high exposure history of cs₂as the workers in spinning department, had greater chance to develop the polyneuropathy or microaneurysm. But there were some limitations to conclude the association between the cs₂exposure and development of polyneuropathy or microaneurysm. Limitations are follows : short follow-up period, small number of cases, and possibility of measurement error including imperfect sensitivity or specificity of electrodiagnostic test and examiner's difference of opthalmoscopic examination. Therefore more cases and longer follow-up period are needed to study the progression of polyneuropathy or microaneurysm.