한국인 정신분열병 환자의 HLA-DQA1,HLA-DQB1 HLA-DRB1 대립유전자 빈도 = HLA-DQA1,HLA-DQB1,and HLA-DRB1 Allele Frequency in Korean Patients with Schizophrenia

국문 초록 (Abstract)

연구목적:
저자들은 PCR-SSOP 방법으로 한국인 정신분열병 환자에서 HLA-DQA1, HLA-DQB1 및 HLA-
DRB1과 정신분열병의 감수성과의 상관성을 밝히고자 하였다.
방법:
DSM-IV 에 의거하여 정신분열병으로 진단된 환자군 128명과 정상대조군 160명에 대해 polymerase chain reaction-sequence specifc oligonucleotide probes(PCR-SSOP) 방법을 이용하여 HLA-DQA1, HLA-DQB1, HLA-DRB1 대립유전자의 빈도를 분석하였다.
결과:
HLA-DQB1□04는 환자군에서 14.6%로 정상대조군의 8.2%보다 높은 빈도를 보였고 (p=0.028), HLA-DRB1□14는 환자군에서 11.8%로 정상대조군으 5.5%보다 높았으며 (p=0.01), HLA-DRB□15는 환자군에서 2.0%로 정상대조군의 7.1%보다 낮은 빈도를 보였고(p=0.007), HLA-DRB□16은 환자군에서 1.6%로 정상대조군의 4.8%에 비해 유의하게 낮았다(p=0.043).
결론:
한국인 정신분열병 환자에서 HLA-DQB1□04와 HLA-DRB1□14S는 질병 발생의 감수성 인자로 작용을 하고, HLA-DRB1□15와 HLA-DRB1□16은 방어적인 역할을 할 수 있다고 할 수 있으나, 다른 인종에 관한 외국의 연구자들의 결과와는 상이한 양상을 보였다.

다국어 초록 (Multilingual Abstract)

Objectives: The aim of this study was to investigate the correlation between HLA-DQA1,HLA-DQB1 and HLA-DRB! alleles and disease susceptibility in Korean schizophrenic patients.
Methods: HLA-DQA1, HLA-DQB1, and HLA-DRB! allele typing were performed using
polymerase chain reaction-sequence specific oligonucleotide probes(PCR-SSOP) method in 128 Korean schizophrenic patients diagnosed by DSM-IV criteria, who were not blood-related, and 160 normal blood bank donors.
Results: The HLA-DQB1□04 allele frequency was 14.6% in schizophrenic patients, which was significantly higher than that of normal controls which was 8.2%(p=0.028). HLA-DRB1□14 allele frequency was 11.8% in patients, which was also more frequent than that of normal controls which was 5.5%(p=0.01). HLA-DRB1□15 allele frequency was 2.0% in patients, which was significantly lower than that of normal controls which was 7.1%(p=0.007) and HLA-DRB1□16 allele frequency was 1.6% in patients, which was also lower than that of normal controls which was 4.8%(p=0.043).
Conclusion: Schizophrenia in Korea had positive correlation with HLA-DQB1□04 and HLA-DRB1□14, and negative correlation with HLA-DRB1□15 and HLA-DRB1□16. These findings support the association of the HLA-DQB1 and HLA-DRB1 with schizophrenia in Korean population, which was different from other study results in other different ethnic groups.

목차 (Table of Contents)

• Ⅰ. 서론
• Ⅱ. 연구대상 및 방법
• 1. 연구대상
• 2. 연구방법
• Ⅲ. 연구결과
• 1. HLA-DQA1 대립유전자(Allele)의 빈도
• 2. HLA-DQB1 대립유전자(Allele)의 빈도
• 3. HLA-DRB1 대립유전자(Allele)의 빈도
• Ⅳ. 고찰
• Ⅴ. 참고문헌