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      KCI등재 SCIE SCOPUS

      Genetic diversity and phylogenetic analysis of porcine reproductive and respiratory syndrome virus in southern China from 2007 to 2014

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      https://www.riss.kr/link?id=A105103260

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      다국어 초록 (Multilingual Abstract)

      Porcine reproductive and respiratory syndrome virus (PRRSV) has a high degree of genetic variation. In this study, we characterized the genetic variation and evolutionary relationships among circulating PRRSV strains in southern China. We analyzed 29 NSP2 strains and 150 ORF5 strains from clinical samples collected in southern China during 2007–2014. The alignment results showed that the nucleotide identity similarities of the two genes among these strains were 80.5%–99.7% and 80.9%–100%, respectively. Phylogenetic analysis based on the NSP2 gene showed that highly pathogenic (HP)-PRRSV was still the dominant virus in southern China from 2013 to 2014. Compared with reference strains CH-1a and VR-2332, the field strain 131101-GD-SHC, which shared high homology with JXA1-P170, had a novel 12 amino acid deletion at position 499-510. Phylogenetic analysis based on the ORF5 gene showed that HP-PRRSV, VR2332-like strains, and QYYZ-like strains were simultaneously circulating in southern China from 2007 to 2014, suggesting that, in recent years, the type 2 PRRSV was more diverse in southern China. In conclusion, mutations in the decoy epitope and primary neutralizing epitope could be markers of viral evolution and used to study evolutionary relationships among PRRSV strains in China.
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      Porcine reproductive and respiratory syndrome virus (PRRSV) has a high degree of genetic variation. In this study, we characterized the genetic variation and evolutionary relationships among circulating PRRSV strains in southern China. We analyzed 29 ...

      Porcine reproductive and respiratory syndrome virus (PRRSV) has a high degree of genetic variation. In this study, we characterized the genetic variation and evolutionary relationships among circulating PRRSV strains in southern China. We analyzed 29 NSP2 strains and 150 ORF5 strains from clinical samples collected in southern China during 2007–2014. The alignment results showed that the nucleotide identity similarities of the two genes among these strains were 80.5%–99.7% and 80.9%–100%, respectively. Phylogenetic analysis based on the NSP2 gene showed that highly pathogenic (HP)-PRRSV was still the dominant virus in southern China from 2013 to 2014. Compared with reference strains CH-1a and VR-2332, the field strain 131101-GD-SHC, which shared high homology with JXA1-P170, had a novel 12 amino acid deletion at position 499-510. Phylogenetic analysis based on the ORF5 gene showed that HP-PRRSV, VR2332-like strains, and QYYZ-like strains were simultaneously circulating in southern China from 2007 to 2014, suggesting that, in recent years, the type 2 PRRSV was more diverse in southern China. In conclusion, mutations in the decoy epitope and primary neutralizing epitope could be markers of viral evolution and used to study evolutionary relationships among PRRSV strains in China.

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      참고문헌 (Reference)

      1 Plagemann PGW., "The primary GP5 neutralization epitope of North American isolates of porcine reproductive and respiratory syndrome virus" 102 : 263-275, 2004

      2 Wissink EHJ, "The major envelope protein, GP5, of a European porcine reproductive and respiratory syndrome virus contains a neutralization epitope in its N-terminal ectodomain" 84 : 1535-1543, 2003

      3 Van Breedam W, "The M/GP5 glycoprotein complex of porcine reproductive and respiratory syndrome virus binds the sialoadhesin receptor in a sialic acid-dependent manner" 6 : e1000730-, 2010

      4 Zhou L, "The 30-amino-acid deletion in the Nsp2 of highly pathogenic porcine reproductive and respiratory syndrome virus emerging in China is not related to its virulence" 83 : 5156-5167, 2009

      5 Meulenberg JJM, "Subgenomic RNAs of Lelystad virus contain a conserved leader-body junction sequence" 74 : 1697-1701, 1993

      6 Keffaber KK, "Reproductive failure of unknown etiology" 1 : 1-9, 1989

      7 Huang C, "Regulation and evasion of antiviral immune responses by porcine reproductive and respiratory syndrome virus" 202 : 101-111, 2015

      8 Yuan S, "Recombination between North American strains of porcine reproductive and respiratory syndrome virus" 61 : 87-98, 1999

      9 Shi M, "Phylogeny-based evolutionary, demographical, and geographical dissection of North American type 2 porcine reproductive and respiratory syndrome viruses" 84 : 8700-8711, 2010

      10 An TQ, "Origin of highly pathogenic porcine reproductive and respiratory syndrome virus, China" 16 : 365-367, 2010

      1 Plagemann PGW., "The primary GP5 neutralization epitope of North American isolates of porcine reproductive and respiratory syndrome virus" 102 : 263-275, 2004

      2 Wissink EHJ, "The major envelope protein, GP5, of a European porcine reproductive and respiratory syndrome virus contains a neutralization epitope in its N-terminal ectodomain" 84 : 1535-1543, 2003

      3 Van Breedam W, "The M/GP5 glycoprotein complex of porcine reproductive and respiratory syndrome virus binds the sialoadhesin receptor in a sialic acid-dependent manner" 6 : e1000730-, 2010

      4 Zhou L, "The 30-amino-acid deletion in the Nsp2 of highly pathogenic porcine reproductive and respiratory syndrome virus emerging in China is not related to its virulence" 83 : 5156-5167, 2009

      5 Meulenberg JJM, "Subgenomic RNAs of Lelystad virus contain a conserved leader-body junction sequence" 74 : 1697-1701, 1993

      6 Keffaber KK, "Reproductive failure of unknown etiology" 1 : 1-9, 1989

      7 Huang C, "Regulation and evasion of antiviral immune responses by porcine reproductive and respiratory syndrome virus" 202 : 101-111, 2015

      8 Yuan S, "Recombination between North American strains of porcine reproductive and respiratory syndrome virus" 61 : 87-98, 1999

      9 Shi M, "Phylogeny-based evolutionary, demographical, and geographical dissection of North American type 2 porcine reproductive and respiratory syndrome viruses" 84 : 8700-8711, 2010

      10 An TQ, "Origin of highly pathogenic porcine reproductive and respiratory syndrome virus, China" 16 : 365-367, 2010

      11 Wang FX, "Novel Nsp2deletion based on molecular epidemiology and evolution of porcine reproductive and respiratory syndrome virus in Shandong Province from 2013 to 2014" 33 : 219-226, 2015

      12 Wei Z, "N-linked glycosylation of GP5 of porcine reproductive and respiratory syndrome virus is critically important for virus replication in vivo" 86 : 9941-9951, 2012

      13 Wensvoort G, "Mystery swine disease in The Netherlands:the isolation of Lelystad virus" 13 : 121-130, 1991

      14 Chenna R, "Multiple sequence alignment with the Clustal series of programs" 31 : 3497-3500, 2003

      15 Zhou L, "Molecular variation analysis of porcine reproductive and respiratory syndrome virus in China" 145 : 97-105, 2009

      16 Han W, "Molecular mutations associated with the in vitro passage of virulent porcine reproductive and respiratory syndrome virus" 38 : 276-284, 2009

      17 Xie J, "Molecular epidemiology of PRRSV in South China from 2007 to 2011 based on the genetic analysis of ORF5" 63 : 30-36, 2013

      18 Tamura K, "MEGA5: Molecular Evolutionary Genetics Analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods" 28 : 2731-2739, 2011

      19 Meulenberg JJM, "Lelystad virus, the causative agent of porcine epidemic abortion and respiratory syndrome (PEARS), is related to LDV and EAV" 192 : 62-72, 1993

      20 Ansari IH, "Influence of N-linked glycosylation of porcine reproductive and respiratory syndrome virus GP5 on virus infectivity, antigenicity, and ability to induce neutralizing antibodies" 80 : 3994-4004, 2006

      21 Cano JP, "Impact of a modified-live porcine reproductive and respiratory syndrome virus vaccine intervention on a population of pigs infected with a heterologous isolate" 25 : 4382-4391, 2007

      22 Murtaugh MP, "Immunological responses of swine to porcine reproductive and respiratory syndrome virus infection" 15 : 533-547, 2002

      23 Fang Y, "Heterogeneity in Nsp2 of European-like porcine reproductive and respiratory syndrome viruses isolated in the United States" 100 : 229-235, 2004

      24 Li Y, "Genomic analysis of two Chinese strains of porcine reproductive and respiratory syndrome viruses with different virulence" 40 : 374-381, 2010

      25 Li Y, "Genetic variation analysis of porcine reproductive and respiratory syndrome virus isolated in China from 2002 to 2007 based on ORF5" 138 : 150-155, 2009

      26 Yin G, "Genetic diversity of the ORF5 gene of porcine reproductive and respiratory syndrome virus isolates in Southwest China from 2007 to 2009" 7 : e33756-, 2012

      27 Nilubol D, "Genetic diversity of the ORF5 gene of porcine reproductive and respiratory syndrome virus (PRRSV) genotypes I and II in Thailand" 158 : 943-953, 2013

      28 Wang X, "Genetic diversity and phylogenetic analysis of porcine reproductive and respiratory syndrome virus isolates in East China" 24 : 193-201, 2014

      29 An TQ, "Genetic diversity and phylogenetic analysis of glycoprotein 5 of PRRSV isolates in mainland China from 1996 to 2006:coexistence of two NA-subgenotypes with great diversity" 123 : 43-52, 2007

      30 Costers S, "GP4 of porcine reproductive and respiratory syndrome virus contains a neutralizing epitope that is susceptible to immunoselection in vitro" 155 : 371-378, 2010

      31 Leng X, "Evaluation of the efficacy of an attenuated live vaccine against highly pathogenic porcine reproductive and respiratory syndrome virus in young pigs" 19 : 1199-1206, 2012

      32 Li B, "Epidemiology and evolutionary characteristics of the porcine reproductive and respiratory syndrome virus in China between 2006 and 2010" 49 : 3175-3183, 2011

      33 Tian K, "Emergence of fatal PRRSV variants: unparalleled outbreaks of atypical PRRS in China and molecular dissection of the unique hallmark" 2 : e526-, 2007

      34 Li Y, "Emergence of a highly pathogenic porcine reproductive and respiratory syndrome virus in the Mid-Eastern region of China" 174 : 577-584, 2007

      35 Faaberg KS, "Disulfide bonds between two envelope proteins of lactate dehydrogenase-elevating virus are essential for viral infectivity" 69 : 613-617, 1995

      36 Dea S, "Current knowledge on the structural proteins of porcine reproductive and respiratory syndrome (PRRS) virus:comparison of the North American and European isolates" 145 : 659-688, 2000

      37 Lu W, "Complete genome sequence of a novel variant porcine reproductive and respiratory syndrome virus (PRRSV)strain: evidence for recombination between vaccine and wild-type PRRSV strains" 86 : 9543-, 2012

      38 Du Y, "Complete genome sequence of a moderately pathogenic porcine reproductive and respiratory syndrome virus variant strain" 86 : 13883-13884, 2012

      39 Yuan S, "Complete genome comparison of porcine reproductive and respiratory syndrome virus parental and attenuated strains" 79 : 189-200, 2001

      40 An TQ, "Comparative genomic analysis of five pairs of virulent parental/attenuated vaccine strains of PRRSV" 149 : 104-112, 2011

      41 Leng CL, "Characterization of two newly emerged isolates of porcine reproductive and respiratory syndrome virus from Northeast China in 2013" 171 : 41-52, 2014

      42 Benfield DA, "Characterization of swine infertility and respiratory syndrome (SIRS) virus (isolate ATCC VR-2332)" 4 : 127-133, 1992

      43 Holtkamp DJ, "Assessment of the economic impact of porcine reproductive and respiratory syndrome virus on United States pork producers" 21 : 72-84, 2013

      44 Liu C, "Analysis of genetic variation of porcine reproductive and respiratory syndrome virus (PRRSV) isolates in central China" 78 : 641-648, 2016

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      2023 평가예정 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
      2020-01-01 평가 등재학술지 유지 (해외등재 학술지 평가) KCI등재
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