급성백혈병의 항암화학요법시 Ciprofloxacin의 감염예방효과에 관한 비교연구 = A Comparative Study of Ciprofloxacin for Prevention of Infections in Patients with Acute Leukemia during Chemotherapy

다국어 초록 (Multilingual Abstract)

We evaluated the effect of ciprofloxacin, 500mg given orally every 12hours, on the prevention of bacterial infections in 40 patients receiving anticancer chemotherapy for acute leukemia. Nineteen patients were randomly assigned to receive ciprofloxacin, twenty-one patients assigned as control group did not receive any prophylactic antibioties.
The rate of febrile episodes, microbiologically documented infection, clinically documented infection, possible infection, and mortality were similar in the two groups. There were no significant difference in the duration of granulocytopenia, use of parenteral antibiotics.
Although streptococcal bacteremia occurred in only ciprofloxacin group(2cases), and gram-negative bacteremia occurred in only control group(4 cases), no difference was seen statistically.