Arterial blood pressure, heart rate and rate pressure product changes following tracheal intubation were studied in 49 patients undergoing elective surgical procedures who received a thiopental-succinylcholine anesthetic intubation sequences.
Two tre...
Arterial blood pressure, heart rate and rate pressure product changes following tracheal intubation were studied in 49 patients undergoing elective surgical procedures who received a thiopental-succinylcholine anesthetic intubation sequences.
Two treatment groups and a control group were observed.
Intravenous nicardipine doses of 20 mcg/kg and 30 mcg/kg, injected prior to anesthesia, were compared with respect to effect on the cardiovascular sequences to direct larygoscopy followed by the passage of an endotracheal tube.
The increase in heart rate and rat pressure product associated with tracheal intubation were insignificantly prevented in nicardipine treated patient.
The increase in arterial pressure was prevented, insignificantly. However, it was dose-depending.
From the above resulr, a pre-induction dose of nicardipine was effective in attenuating the pressure response to laryngoscopy and intubation.