Estrogen과 Androgen이 웅성 백서의 신장에 미치는 영향에 대한 병리학적 연구 = A Pathologic Study of the Effects of Estrogen and Androgen on Kidney in Male Rats

다국어 초록 (Multilingual Abstract)

A pathologic study was performed to study the effects of estrogen and androgen on kidney, which was thought to induce benign prostatic hyperplasia in the human and the dog. Forty male Sprague Dawley rats were castrated via a scrotal incision. The remaining 10 rats served as normal controls. A two week period was allowed for the sex accessory tissues of castrated rats to involute after which the rats received 25 daily intramuscular injections of 2mg testosterone only, 0.02mg of estradiol only, or a combination of both steroids, each dissolved in 0.2m1 of propylene glycol. Normal and castrate control groups were injected with 0.2m1 of propylene glycol only. Twenty four hours after the last injection, rats were killed and weighed, and then both kidneys were removed and weighed.
Light microscopic and electron microscopic studies of the kidneys were performed.
The results were as follows:
1. There was a significant increase in the average weight of the kindeys of the groups treated with testosterone plus estradiol when compared to control group (p<0.01).
2. The average weight of the groups treated with testosterone plus estradiol showed a significant decrease compared to those of castrated controls (p<0.05).
3. In the castrate controls, the kidneys were microscopically unremarkable, but the kidneys of the groups treated with testosterone only and estradiol only showed mild vesicle formation in the cytoplasm. The groups treated with testosterone plus estradiol showed enlargement of convoluted tubules and severe vesicle formation.
4. Electron microscopically, the kidneys of the groups treated with testosterone only and estradiol only showed mild edematous change in the cytoplasm, but the groups treated with testosterone plus estradiol showed severe edematous change in mitochondrias and increase of polyribosomes.
The above results suggest that the increased weight of the kidney and tubular er largement of The groups treated with testosterone plus estradiol is caused by water accumulationin the cytoplasm.