Review : The genetics of osteoporosis = Review : The genetics of osteoporosis

다국어 초록 (Multilingual Abstract)

Osteoporosis is a common disease with a strong genetic component, and is characterized by reduced bone mass and increased risk of fragility fractures. Twin and family studies have shown that the heritability of bone mineral density (BMD) and other determinants of fracture risk is high. Many different genetic variants are likely to contribute to the regulation of these phenotypes by interacting with environmental factors, medications, and co-existing diseases. In many instances, subtle polymorphisms in genes have also been found to regulate BMD in the general population. Although there has been extensive progress in identifying the genetic variants that regulate susceptibility to osteoporosis, most of the genes and genetic variants that regulate bone mass and susceptibility to osteoporosis remain to be determined.