^(13)C-Octanoic acid 호기 위 배출 검사의 방법에 따른 비교 = Comparison of the ^(13)C-octanoic acid breath gastric emptying test according to the mathematical models

다국어 초록 (Multilingual Abstract)

Aim: To compare the accuracies of two mathematical models (non-linear vs. linear model), which is currently available, in the measurement of gastric emptying using ^(13)C-octanoic acid breath test.
Method: In twenty healthy volunteers, gastric emptying of solids were measured by simultaneous scintigraphy and ^(13)C-octanoic acid breath test up to 4 hours. Gastric half-emptying times (t_(1/2)) and LAG times (t_(lag)) by breath test were analyzed using non-linear model and generalized linear model, and compared with those by scintigraphy.
Results: In the comparisons of gastric emptying t_(lag), the breath test results were overestimate the scintigraphic results. The standard diviation of difference was 168 minutes (range 0 to 777) by non-linear method and 29 minutes (6 to 116) by linear method. For the t_(1/2), the breath test results were also overestimate the scintigraphic results. The standard diviation of difference was 538 minutes (range -3 to 2,406) by non-linear method and 72 minutes (-11 to 315) by linear method.
Conclusions: Linear model looks more acurate than non-linear model in the measurement of gastric emptying using ^(13)C-octanoic acid breath test. However, two methods still shows overestimation compared to scintigraphic results, suggesting need for the development of accurate method of ^(13)C-octanoic acid gastric emptying breath test.