Use of Porcine-derived Block Bone Substitutes for Guided Bone Regeneration in the Peri-implant Dehiscence Defects of the Mandibular Anterior Region

다국어 초록 (Multilingual Abstract)

Purpose: Various bone graft materials are currently used for guided bone regeneration (GBR), but data are lacking on the superiority of one biomaterial relative to the other. In addition, achieving successful bone augmentation remains challenging. When used in GBR, block bone substitutes show better augmentation stability of the bone than particulated bone substitutes. Recently developed softtype block bone substitutes are widely used in clinical practice.
Materials and Methods: This study enrolled 12 patients who underwent implant placement with GBR in the mandibular anterior region between September 2016 and May 2021 in the Department of Periodontology, Daejeon Dental Hospital, Wonkwang University. GBR was performed using demineralized porcine bone mineral with 10% collagen (DPBM-C; LegoGraft®) and a resorbable collagen membrane (Bio-Gide® or Ossix Plus®). The surgical site was sutured with 4-0 e-PTFE (Biotex®) and 5-0 nylon (Monosof®) by using modified horizontal mattress and interrupted suture methods. Stitch-out was performed two weeks af ter the operation, and reentry surgery was performed within four to six months after the implant surgery.
Results: There was a significant decrease in bone thickness after five months of implant surgery with GBR compared with the decrease immediately after surgery. However, bone gains of more than 1.5 mm were observed at all measurement sites compared with those at baseline.
Conclusion: GBR performed using demineralized porcine bone mineral with 10% collagen in combination with a resorbable collagen membrane is an effective and favorable treatment modality for peri-implant dehiscence defects in terms of clinical and radiographic outcomes during the healing period.

참고문헌 (Reference)

1 Benic GI, "block xenogenic bone substitutes : a pilot cone beam computed tomographic investigation" 28 : e262-e270, 2017

2 Urban IA, "Vertical Bone Grafting and Periosteal Vertical Mattress Suture for the Fixation of Resorbable Membranes and Stabilization of Particulate Grafts in Horizontal Guided Bone Regeneration to Achieve More Predictable Results: A Technical Report" 36 : 153-159, 2016

3 Temmerman A, "The outcome of oral implants placed in bone with limited bucco-oral dimensions : a 3-year follow-up study" 42 : 311-318, 2015

4 Mertens C, "The influence of wound closure on graft stability : An in vitro comparison of different bone grafting techniques for the treatment of one-wall horizontal bone defects" 21 : 284-291, 2019

5 Cordaro L, "Retrospective evaluation of mandibular incisor replacement with narrow neck implants" 17 : 730-735, 2006

6 Simonis P, "Long-term implant survival and success : a 10-16-year followup of non-submerged dental implants" 21 : 772-777, 2010

7 Howe MS, "Long-term (10-year) dental implant survival: A systematic review and sensitivity meta-analysis" 84 : 9-21, 2019

8 Mir-Mari J, "Influence of blinded wound closure on the volume stability of different GBR materials : an in vitro cone-beam computed tomographic examination" 27 : 258-265, 2016

9 Quirynen M, "Implant therapy : 40 years of experience" 66 : 7-12, 2014

10 Benic GI, "Horizontal bone augmentation by means of guided bone regeneration" 66 : 13-40, 2014

11 Benic GI, "Guided bone regeneration of peri-implant defects with particulated and block xenogenic bone substitutes" 27 : 567-576, 2016

12 Elgali I, "Guided bone regeneration : materials and biological mechanisms revisited" 125 : 315-337, 2017

13 Lee JH, "Effect of enamel matrix derivative on alveolar ridge preservation in the posterior maxilla: A randomized controlled clinical trial" 22 : 622-630, 2020

14 Rakhmatia YD, "Current barrier membranes : titanium mesh and other membranes for guided bone regeneration in dental applications" 57 : 3-14, 2013

15 Lee JH, "Comparative assessment of anterior maxillary alveolar ridge preservation with and without adjunctive use of enamel matrix derivative: A randomized clinical trial" 31 : 1-9, 2020

16 Jung EH, "Augmentation stability and early wound healing outcomes of guided bone regeneration in peri-implant dehiscence defects with L- and I-shaped soft block bone substitutes:A clinical and radiographic study" 32 : 1308-1317, 2021

17 Lee JH, "Assessment of early discomfort and wound healing outcomes after periodontal surgery with and without enamel matrix derivative: an observational retrospective case-control study" 24 : 229-237, 2020

18 Balshi TJ, "A long-term retrospective analysis of survival rates of implants in the mandible" 30 : 1348-1354, 2015

19 Koo TK, "A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research" 15 : 155-163, 2016

20 Wang HL, ""PASS"principles for predictable bone regeneration" 15 : 8-17, 2006