Can the Mean Platelet Volume Be a Risk Factor for Vasculogenic Erectile Dysfunction?

다국어 초록 (Multilingual Abstract)

Purpose: The mean platelet volume (MPV) is a marker of the platelet activity and is reported to increase in vascular diseases. We aimed to investigate the association between MPV and vasculogenic erectile dysfunction (ED). Materials and Methods: MPV and platelet (PLT) levels were measured in 50 cases of ED and 40 healthy controls. The diagnosis of vasculogenic ED was based on a detailed sexual history, physical examination, laboratory assessment, and color Doppler ultrasonography. The results are given as mean±standard deviation of the mean. Results: The mean ages of the patient and the control groups were 53.70±12.39 years (range 24∼77 years) and 53.85±9.5 years (range 30∼73 years), respectively (p=0.947). The MPV and PLT values were significantly higher in the patients with ED than those of the controls (7.49±1.4), (6.85±1.2), (262.97±68), (252.89±82) respectively, p＜0.001). However, the MPV values were not statistically significantly different in the patients with severe ED according to the International Index of Erectile Function than in those with mild ED, p＞0.05), and there was no correlation between MPV and either age of patients (p=0.905) or duration of ED (p=0.583). Conclusions: The platelet count and MPV was detected to be increased in patients with vasculogenic ED. This finding suggests a role for platelets in the pathogenesis of vascular complications and that the MPV would be useful in monitoring disease progression.

참고문헌 (Reference)

1 Montorsi P, "The triad of endothelial dysfunction, cardiovascular disease, and erectile dysfunction: clinical implications" 8 : 58-66, 2009

2 Coban E, "The mean platelet volume in patients with obesity" 59 : 981-982, 2005

3 Ayta IA, "The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences" 84 : 50-56, 1999

4 Boos CJ, "The effects of coronary artery disease severity on time-dependent changes in platelet activation indices in stored whole blood" 25 : 135-140, 2008

5 Bacon CG, "Sexual function in men older than 50 years of age: results from the health professionals follow- up study" 139 : 161-168, 2003

6 Clark NG, "SHIELD Study Group. Symptoms of diabetes and their association with the risk and presence of diabetes: findings from the Study to Help Improve Early evaluation and management of risk factors Leading to Diabetes (SHIELD)" 30 : 2868-2873, 2007

7 Bozkurt Y, "Relationship between mean platelet volume and varicocele: a preliminary study" 79 : 1048-1051, 2012

8 Stokes KY, "Platelets: a critical link between inflammation and microvascular dysfunction" 590 : 1023-1034, 2012

9 Khandekar MM, "Platelet volume indices in patients with coronary artery disease and acute myocardial infarction: an Indian scenario" 59 : 146-149, 2006

10 Nadar S, "Platelet morphology and plasma indices of platelet activation in essential hypertension: effects of amlodipine-based antihypertensive therapy" 36 : 552-557, 2004

11 Kamath S, "Platelet activation: assessment and quantification" 22 : 1561-1571, 2001

12 Simonsen U, "Penile arteries and erection" 39 : 283-303, 2002

13 Yang A, "Mean platelet volume as marker of restenosis after percutaneous transluminal coronary angioplasty in patients with stable and unstable angina pectoris" 117 : 371-377, 2006

14 Chu SG, "Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis" 8 : 148-156, 2010

15 Montorsi P, "Is erectile dysfunction the "tip of the iceberg" of a systemic vascular disorder?" 44 : 352-354, 2003

16 Vlachopoulos C, "Inflammation, metabolic syndrome, erectile dysfunction, and coronary artery disease: common links" 52 : 1590-1600, 2007

17 Chung SD, "Increased risk of stroke among men with erectile dysfunction: a nationwide population-based study" 8 : 240-246, 2011

18 Mittawae B, "Incidence of erectile dysfunction in 800 hypertensive patients: a multicenter Egyptian national study" 67 : 575-578, 2006

19 Corona G, "Hypogonadism as a risk factor for cardiovascular mortality in men: a meta-analytic study" 165 : 687-701, 2011

20 Dong JY, "Erectile dysfunction and risk of cardiovascular disease: meta-analysis of prospective cohort studies" 58 : 1378-1385, 2011

21 Lewis RW, "Definitions/epidemiology/risk factors for sexual dysfunction" 7 : 1598-1607, 2010

22 Coppinger JA, "Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions" 103 : 2096-2104, 2004

23 Yaşar AS, "Association between admission mean platelet volume and coronary patency after thrombolytic therapy for acute myocardial infarction" 38 : 85-89, 2010

24 Mehta A, "Assessment of EndoPAT scores in men with vasculogenic and non-vasculogenic erectile dysfunction" 67 : 46-51, 2013

25 Inman BA, "A population-based, longitudinal study of erectile dysfunction and future coronary artery disease" 84 : 108-113, 2009