하수오 추출물 투여가 Streptozotocin으로 유발된 당뇨 흰쥐의 항산화작용에 미치는 효과 = Antioxidative Effect of Polygoni radix in Streptozotocin-Induced Diabetic Rats

다국어 초록 (Multilingual Abstract)

This study was done to investigate the antioxidative effect of polygoni radix in Streptozotocin (STZ)-induced diabetic
rats. Diabetes was induced by intravenous injection of STZ at a dose of 45 mg/kg dissolved in citrate buffer. The ethanol
extract of Polygoni radix was orally administrated once a day for 7 days. The contents of Total cholesterol, triglyceride (TG)
were significantly decreased in Polygoni radix treated STZ-sample group compared with to the those of STZ-control group.
The hepatic cytosolic activities of glutathione-s-transferase (GST), superoxide dismutase (SOD) were significantly increased,
Also the content of glutathione (GSH) was incresaed in Polygoni radix treated STZ-sample group compared with to the those
of STZ-control group. but the content of malondialdehyde (MDA) and the hepatic cytosolic activity of Catalase (CAT) were
decreaed but not statistical significant. These results indicated that ethanol extract of polygoni radix was effective for the antidxidative
in the STZ-induced diabetic rats.

참고문헌 (Reference)

1 김옥경, "하수오 추출물의 혈당강하작용" 한국유화학회 25 (25): 347-354, 2008

2 이정숙, "말굽버섯 추출물이 Streptozotocin으로 유발된 당뇨 흰쥐의 혈당, 지질대사 및 면역세포에 미치는 영향" 한국식품영양과학회 34 (34): 825-832, 2005

3 김옥경, "구기자 분획물이 Streptozotocin으로 유발 된 당뇨 흰쥐에 대한 항당뇨 및 항산화작용에 미치는 효과" 한국생약학회 40 (40): 128-136, 2009

4 임현정, "고지혈증 환자에서 의학영양치료와 병행하여 섭취한 기능성차(상엽, 구기자, 국화, 대추, 참깨, 나복자)의 혈중 지질 농도 저하 및 항산화 효과" 한국식품영양과학회 34 (34): 42-56, 2005

5 방미애, "Streptozotocin-유발당뇨쥐에서 함초첨가 식이의 항당뇨 및 항산화 효과" 한국식품영양과학회 31 (31): 840-846, 2002

6 Takasu, N., "Streptozotocin and alloxan induced H2O2generationand DNA fragmentation a pancreatic islets" 40 : 1141-1145, 1991

7 Neuzil, J., "Radicalinducedchain oxidation of proteins and its inhibition by chainbreaking antioxidants" 293 : 601-606, 1993

8 Cropo, C. H., "Preparationand Assay of Superoxide Dismutase. in: Methods in Enzymology" AcademicPress 382-, 1978

9 Kim, N. J, "Pharmacologicaleffects of Lycium chinensis" 25 : 264-270, 1994

10 Chow, C. K., "Nutritional influence on cellular antioxidationdefence systems" 32 : 1066-1081, 1979

11 L. Pari, "Modulatory Effect of Scoparia dulcis in Oxidative Stress-Induced Lipid Peroxidation in Streptozotocin Diabetic Rats" 한국식품영양과학회 6 (6): 379-386, 2003

12 Yoon, C. K., "Hepatic oxygen free radical and alcohol metabolizingenzyme activities in rats fed diet supplemented withLycium chinense ethanol extract" 30 : 668-671, 2001

13 Ji, H. J., "Health foods from herbs" seoul national universitypublish 168-169, 1999

14 Vos, R. M., "Glutathione-S-transferasein Relation to Their Role in the Biotransformation ofXenobiotics" 75 : 241-265, 1990

15 Hassan,H.M., "Free Radical" 5 : 377-384, 1988

16 Byers, T., "Dietary Carotenes, Vitamin Cand Vitamin E as Protective Antioxidants in Human Cancers" 12 : 135-140, 1992

17 Asyama, K., "Chemiluminescenceas an index of drug induced free radical productionin pancreatic islets" 33 : 160-163, 1984

18 Lee, S. Z., "Changes in vivolipid peroxidation and antioxidant defense system in streptozotocininduced diabetic rats: a time course study" 34 : 253-264, 2001

19 Stein Berg, D., "Beyond cholesterol, modifications oflow-density lipoproteins That increase Its atherogenicity" 320 : 915-923, 1989